[Proposal of a new procedure for the exploration of hepatocellular function. The trimethoxybenzene test (TMB)].

Abstract

The authors propose a new method of exploration of liver cell function based on the study of demethylation of a rapidly assimilated atoxic compound, trimethoxybenzene (TMB) in dimethoxy-hydroxybenzene (DMHB). Whereas in normal subjects, the urinary excretion of the metabolites was rapid and marked, 180 mg within 3 hours after taking a 400 mg dose, in patients with liver cell failure, the excretion of DMHB was considerably reduced, 80 to 95% in cirrhosis.

• Authors: F Rousselet, G Fredj, M Clenet
• Journal: Annales de biologie clinique (Ann Biol Clin (Paris)) Vol. 34 Issue 5 Pg. 323-8 ( 1976) ISSN: 0003-3898 [Print] France
• Vernacular Title: Proposition d'un nouveau procédé d'exploration de la fonction hépatocellulaire. Le "test au triméthoxybenzène" (TMB)
• PMID: 1015669 (Publication Type: English Abstract, Journal Article)

Chemical References

• Benzene Derivatives

Topics

• Benzene Derivatives (metabolism)
• Humans
• Liver Cirrhosis (diagnosis)
• Liver Function Tests (methods)