[In vitro metabolism of ubiquinone and ubichromenol in the livers of rats with avitaminosis E during individual and combined addition of alpha-tocopherol and phenylalanine].

Abstract

A maximal incorporation of 2-14C-acetate into ubiquinone and ubichromenol was found within 3 hrs if liver tissue homogenate of E-avitaminous rats was incubated for 4 hrs. Phenylalanine, added to the mixture, stimulated the biosynthesis of ubiquinone and ubichromenol in the liver tissue preparations. alpha-Tocopherol caused an increase in biosynthesis of ubiquinone and a decrease in the rate of ubichromenol biosynthesis within 1 hr and 3 hrs of incubation in vitro. The combined addition of phenylalanine and alpha-tocopherol, almost without exceptions, increased the effect of alpha-tocopherol on biosynthesis of the substances studied. Interrelationship is discussed between vitamin E and ubiquinone and ubichromenol biosynthesis.

• Authors: G V Donchenko, L A Chernukhina, O M Zolotashko, L Iu Teplitskaia
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1976 Sep-Oct Vol. 22 Issue 5 Pg. 691-6 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Izuchenie in vitro obmena ubikhinona i ubikhromenola v pecheni E-avitaminoznykh krys pri razdel'nom i sovmestnom dobavlenii alpha-tokoferola i fenilalanina
• PMID: 1014483 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ubiquinone
• Vitamin E
• Phenylalanine

Topics

• Animals
• Liver (metabolism)
• Phenylalanine (administration & dosage, therapeutic use)
• Rats
• Ubiquinone (metabolism)
• Vitamin E (administration & dosage, therapeutic use)
• Vitamin E Deficiency (drug therapy)