Abstract |
A case of heparin resistance and its management during cardiopulmonary bypass is reported. A patient with a history of post- infarct angina and arrhythmias was treated with intravenous heparin infusion for five days prior to myocardial revascularisation surgery. He required 13,500 IU/kg of heparin to increase his activated clotting time to a therapeutic level for safe institution of cardiopulmonary bypass. This phenomenon of heparin resistance was postulated to be due to consumption of circulating antithrombin III as a result of prior heparinisation. Treatment with fresh frozen plasma restored heparin effectiveness.
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Authors | C K Leong, B C Ong |
Journal | Annals of the Academy of Medicine, Singapore
(Ann Acad Med Singap)
Vol. 27
Issue 6
Pg. 877-9
(Nov 1998)
ISSN: 0304-4602 [Print] Singapore |
PMID | 10101569
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Aged
- Anticoagulants
(administration & dosage, adverse effects)
- Antithrombin III Deficiency
(chemically induced)
- Blood Coagulation
(drug effects)
- Cardiopulmonary Bypass
- Drug Resistance
- Heparin
(administration & dosage, adverse effects)
- Humans
- Infusions, Intravenous
- Male
- Whole Blood Coagulation Time
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