Abstract |
Among a series of taxinine (1) and its designed derivatives (2-33), two taxoids (29 and 33) increased cellular accumulation of vincristine in multidrug-resistant tumor cells more potently than verapamil, while the activities of eight taxoids (11, 14-16, 22, and 30-32) were comparable with that of verapamil. These results reveal that some taxinine derivatives are good modifiers of multidrug resistance in tumor cells.
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Authors | H Hosoyama, H Shigemori, A Tomida, T Tsuruo, J Kobayashi |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 9
Issue 3
Pg. 389-94
(Feb 08 1999)
ISSN: 0960-894X [Print] England |
PMID | 10091690
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Bridged-Ring Compounds
- Vincristine
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(pharmacokinetics)
- Bridged-Ring Compounds
(chemistry, pharmacology)
- Drug Resistance, Multiple
- Drug Synergism
- Humans
- Mice
- Tumor Cells, Cultured
- Vincristine
(pharmacokinetics)
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