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Modulation of multidrug resistance in tumor cells by taxinine derivatives.

Abstract
Among a series of taxinine (1) and its designed derivatives (2-33), two taxoids (29 and 33) increased cellular accumulation of vincristine in multidrug-resistant tumor cells more potently than verapamil, while the activities of eight taxoids (11, 14-16, 22, and 30-32) were comparable with that of verapamil. These results reveal that some taxinine derivatives are good modifiers of multidrug resistance in tumor cells.
AuthorsH Hosoyama, H Shigemori, A Tomida, T Tsuruo, J Kobayashi
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 9 Issue 3 Pg. 389-94 (Feb 08 1999) ISSN: 0960-894X [Print] England
PMID10091690 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Bridged-Ring Compounds
  • Vincristine
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (pharmacokinetics)
  • Bridged-Ring Compounds (chemistry, pharmacology)
  • Drug Resistance, Multiple
  • Drug Synergism
  • Humans
  • Mice
  • Tumor Cells, Cultured
  • Vincristine (pharmacokinetics)

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