Complete remission of refractory anemia following a single high dose of cyclophosphamide.

Abstract

We describe a case of stable complete remission in a patient with refractory anemia complicated by severe autoimmune hemolytic anemia, achieved with a single high dose (4 g/m2) of cyclophosphamide (cyclo). Concomitantly, an effective mobilization of CD34-positive cells was induced. Other immunosuppressive approaches including high-dose methylprednisolone, high-dose immunoglobulin, and cyclosporine had been ineffective. This finding suggests that, in selected cases, an immunologic mechanism may mediate cytopenia in myelodysplastic syndromes (MDS). In addition, it demonstrates that successful mobilization of peripheral blood stem cells can be induced with high-dose cyclo in MDS.

• Authors: F Ferrara, C Copia, M Annunziata, R di Noto, C Russo, S Palmieri, A Spasiano, L del Vecchio
• Journal: Annals of hematology (Ann Hematol) Vol. 78 Issue 2 Pg. 87-8 (Feb 1999) ISSN: 0939-5555 [Print] Germany
• PMID: 10089024 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulins, Intravenous
• Immunosuppressive Agents
• Cyclosporine
• Cyclophosphamide
• Methylprednisolone

Topics

• Adult
• Anemia, Hemolytic, Autoimmune (complications, drug therapy, pathology, therapy)
• Anemia, Refractory (complications, drug therapy, pathology, therapy)
• Autoimmune Diseases (complications, drug therapy, pathology, therapy)
• Blood Transfusion
• Bone Marrow (pathology)
• Cyclophosphamide (administration & dosage, therapeutic use)
• Cyclosporine (therapeutic use)
• Hematopoietic Stem Cell Mobilization
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Immunosuppressive Agents (administration & dosage, therapeutic use)
• Male
• Methylprednisolone (therapeutic use)
• Remission Induction