Comparison of topical application of oxytetracycline and four nonantibiotic solutions for treatment of papillomatous digital dermatitis in dairy cows.

Abstract

OBJECTIVE:

To compare efficacy of topical treatment with oxytetracycline solution or 1 of 4 nonantibiotic solutions among dairy cows with papillomatous digital dermatitis (PDD).

DESIGN:

Randomized field trial.

ANIMALS:

66 cows in a single herd.

PROCEDURE:

Cows were randomly assigned to be treated with oxytetracycline solution; a commercial formulation of soluble copper, peroxide compound, and a cationic agent; 5% copper sulfate solution; acidified ionized copper solution; hydrogen peroxide-peroxyacetic acid solution; or tap water. Cows were examined 14 and 30 days after initial treatment. During each examination, pain and lesion scores were recorded.

RESULTS:

On the basis of pain and lesion scores, oxytetracycline and the commercial formulation appeared equally effective for treatment of PDD and significantly more effective than 5% copper sulfate solution, acidified ionized copper solution, hydrogen peroxide-peroxyacetic acid solution, and tap water. Proportions of cows with signs of pain or visible lesions after treatment were significantly lower for cows treated with oxytetracycline or the commercial formulation than for cows in the other groups.

CLINICAL IMPLICATIONS:

Oxytetracycline and a commercial formulation of soluble copper, peroxide compound, and a cationic agent appeared to be effective for treatment of PDD in dairy cows.

• Authors: J Hernandez, J K Shearer, J B Elliott
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 214 Issue 5 Pg. 688-90 (Mar 01 1999) ISSN: 0003-1488 [Print] United States
• PMID: 10088020 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents, Local
• Disinfectants
• Fungicides, Industrial
• Oxidants
• Solutions
• Copper
• Hydrogen Peroxide
• Peracetic Acid
• Copper Sulfate
• Oxytetracycline

Topics

• Administration, Topical
• Animals
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Cattle
• Cattle Diseases (drug therapy)
• Copper (administration & dosage, therapeutic use)
• Copper Sulfate (administration & dosage, therapeutic use)
• Disinfectants (administration & dosage, therapeutic use)
• Female
• Foot Dermatoses (drug therapy, veterinary)
• Fungicides, Industrial (administration & dosage, therapeutic use)
• Hoof and Claw
• Hydrogen Peroxide (administration & dosage, therapeutic use)
• Oxidants (administration & dosage, therapeutic use)
• Oxytetracycline (administration & dosage, therapeutic use)
• Peracetic Acid (administration & dosage, therapeutic use)
• Solutions