Trisomy 22 in acute myeloid leukemia: a marker for myeloid leukemia with monocytic features and cytogenetically cryptic inversion 16.

Abstract

Trisomy 22 is an uncommon chromosomal abnormality in acute myeloid leukemia. Recent studies, however, have shown an association between trisomy 22 and acute myeloid leukemia with a monocytic component, and in particular, acute myelomonocytic leukemia with marrow eosinophilia. Furthermore, it has also been suggested that trisomy 22 was in fact only a secondary chromosomal change occurring in acute myeloid leukemia with inv(16). In this report, we analyze the morphological, cytogenetic, and molecular findings of three cases of acute myeloid leukemia with trisomy 22 but without cytogenetic evidence of inv(16). The results indicate a consistent association between trisomy 22 and inv(16), the latter being cytogenetically cryptic in some cases. This finding is of potential diagnostic and therapeutic significance.

• Authors: K F Wong, Y L Kwong
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 109 Issue 2 Pg. 131-3 (Mar 1999) ISSN: 0165-4608 [Print] United States
• PMID: 10087946 (Publication Type: Journal Article)

Chemical References

• Genetic Markers

Topics

• Acute Disease
• Adolescent
• Adult
• Chromosome Inversion
• Chromosomes, Human, Pair 16
• Chromosomes, Human, Pair 22
• Genetic Markers
• Humans
• Leukemia, Myeloid (genetics, pathology)
• Male
• Monocytes (pathology)
• Polymerase Chain Reaction
• Trisomy