Effects of polysulfonate derivative (GL 522-Y-1) on coagulation in vitro and thrombosis in vivo.

Abstract

We have investigated the influence of a polysulfonate derivative - GL 522-Y-1 - on platelet-induced thrombin generation time, platelet adhesion to siliconized glass, platelet aggregation induced by collagen and ADP, on aPTT, PT and TT in vitro and studied its antithrombotic effect in an animal model of thrombosis in vivo. In vitro, GL 522-Y-1 caused inhibition of ADP- and collagen-induced aggregation. In a dose-dependent manner this compound inhibited PITT, aPTT, and PT. GL 522-Y-1 did not prolong thrombin time. GL 522-Y-1 inhibited in vivo the laser-induced thrombus formation after intravenous and oral administration. On the basis of its unique antithrombotic properties, GL 522-Y-1 seems to open a new pathway in the field of antithrombotics.

• Authors: P Radziwon, B Boczkowska-Radziwon, J Giedrojc, J Schenk, M Z Wojtukiewicz, J Kloczko, H K Breddin
• Journal: Haemostasis (Haemostasis) 1998 Mar-Apr Vol. 28 Issue 2 Pg. 86-92 ISSN: 0301-0147 [Print] Switzerland
• PMID: 10087433 (Publication Type: Journal Article)

Chemical References

• Anticoagulants
• GL 522-Y-1
• Platelet Aggregation Inhibitors
• Polymers
• Sulfonic Acids
• Collagen
• Silicon

Topics

• Animals
• Anticoagulants (pharmacology, therapeutic use)
• Collagen
• Humans
• Male
• Platelet Adhesiveness (drug effects)
• Platelet Aggregation (drug effects)
• Platelet Aggregation Inhibitors (pharmacology, therapeutic use)
• Polymers (pharmacology, therapeutic use)
• Rats
• Rats, Wistar
• Silicon
• Sulfonic Acids (pharmacology, therapeutic use)
• Thrombin Time
• Thrombosis (drug therapy)