Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor.

Abstract

Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic disease. The metastatic and refractory cases have a very poor prognosis. To our knowledge, this is the first report of the application of high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT) for the treatment of refractory metastatic PSTT. A 36-year-old woman had a metastatic PSTT refractory to several lines of chemotherapy. She was treated with high dose of carboplatin and etoposide with autologous PBSCT. She showed only a temporary response to high-dose chemotherapy with PBSCT support and died of disease.

• Authors: Y Aoki, S Kodama, H Kurata, H Kase, K Tanaka
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 47 Issue 3 Pg. 214-6 ( 1999) ISSN: 0378-7346 [Print] Switzerland
• PMID: 10087421 (Publication Type: Case Reports, Journal Article)

Chemical References

• Etoposide
• Carboplatin

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carboplatin (administration & dosage)
• Drug Resistance, Neoplasm
• Etoposide (administration & dosage)
• Fatal Outcome
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Hysterectomy
• Ovarian Neoplasms (secondary)
• Ovariectomy
• Pregnancy
• Transplantation, Autologous
• Trophoblastic Tumor, Placental Site (secondary, therapy)
• Uterine Neoplasms (pathology, therapy)