Management of renal colic with intranasal desmopressin spray.

Abstract

This study evaluates the effectiveness of desmopressin renal spray, an antidiuretic drug, in treating patients with acute renal colic. One hundred and eight patients admitted to the emergency room of our hospitals with acute renal colic were included in the study. Each patient, except those with hypertension or other cardiac insufficiency, received 40 micrograms desmopressin intranasal spray. In 58 patients (53.7%) pain was eliminated 30 min after desmopressin administration. Forty-four patients (40.7%) did not respond to desmopressin and received prostaglandin synthesis inhibitors, while another 6 patients required intramuscular pethidine for pain relief. No patient showed any side effects. We conclude that the simplicity and effectiveness of intranasal desmopressin spray in treating renal colic makes this simple method a useful means of confronting a frequent and disturbing urological problem.

• Authors: C Constantinides, V Kapralos, T Manousakas, D Mitropoulos, C Alamanis, C Dimopoulos
• Journal: Acta urologica Belgica (Acta Urol Belg) Vol. 66 Issue 4 Pg. 1-3 (Dec 1998) ISSN: 0001-7183 [Print] Belgium
• PMID: 10083625 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Renal Agents
• Deamino Arginine Vasopressin

Topics

• Administration, Intranasal
• Adult
• Colic (drug therapy)
• Deamino Arginine Vasopressin (administration & dosage)
• Humans
• Kidney Diseases (drug therapy)
• Middle Aged
• Renal Agents (administration & dosage)