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Identification of TAXREB107 as an erythropoietin early response gene.

Abstract
The protooncogenes c-myc and c-myb are erythropoietin (Epo)-regulated early response genes. They appear to play distinct roles in the growth- and differentiation-inducing signals of the hormone. Using a subtractive hybridization strategy, we have identified the murine homolog of the TAX response element-binding protein TAXREB107 as an Epo early response gene in Rauscher murine erythroleukemia cells. This was confirmed by Northern blot analyses, which showed a fourfold increase in TAXREB107 mRNA after 1 hr of erythropoietin treatment. After 3 hr the transcript had decreased to approximately twofold above control levels. Inhibition of this induction with antisense oligodeoxynucleotides increased Epo-induced hemoglobinization 2.5-fold. The results implicate TAXREB107 in erythropoiesis and support the hypothesis that the TAXREB proteins have functions outside the context of HTLV-I infection.
AuthorsR Li, H Madden, A J Sytkowski
JournalAIDS research and human retroviruses (AIDS Res Hum Retroviruses) Vol. 15 Issue 4 Pg. 375-9 (Mar 01 1999) ISSN: 0889-2229 [Print] United States
PMID10082121 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • DNA-Binding Proteins
  • tax-responsive-element-binding protein 107, mouse
  • Erythropoietin
Topics
  • Animals
  • DNA-Binding Proteins (genetics)
  • Erythropoietin (metabolism, pharmacology)
  • Humans
  • Mice
  • Tumor Cells, Cultured

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