Abstract | PURPOSE: In patients undergoing cytokine therapy, systemically applied interleukin-2 (IL-2) and/or interferon-alpha (IFN-alpha) have been reported to induce thyroid dysfunction as well as thyroid autoantibodies. We analyzed the correlation of thyroid autoimmunity with HLA phenotype, various other autoimmune parameters, and patient survival. PATIENTS AND METHODS: RESULTS:
Antithyroglobulin autoantibodies and antimicrosomal thyroid autoantibodies were detected in 60 patients (18%); positive autoantibody titers of various other autoimmune parameters were statistically unrelated. The presence of thyroid autoantibodies was correlated with prolonged survival (P<.0001). There was a statistically significant difference in frequencies of HLA-Cw7 expression between thyroid autoantibody-positive and -negative patients (P< or =.05), and the Cw7 expression was associated with prolonged overall survival (P = .009). CONCLUSION:
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Authors | A Franzke, D Peest, M Probst-Kepper, J Buer, G I Kirchner, G Brabant, H Kirchner, A Ganser, J Atzpodien |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 17
Issue 2
Pg. 529-33
(Feb 1999)
ISSN: 0732-183X [Print] United States |
PMID | 10080596
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antibodies, Neoplasm
- Autoantibodies
- HLA Antigens
- Interferon-alpha
- Interleukin-2
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Topics |
- Adult
- Aged
- Antibodies, Neoplasm
(blood)
- Autoantibodies
(blood)
- Autoimmunity
(drug effects)
- Carcinoma, Renal Cell
(immunology, secondary, therapy)
- Female
- HLA Antigens
(immunology)
- Humans
- Immunotherapy
- Interferon-alpha
(therapeutic use)
- Interleukin-2
(adverse effects, therapeutic use)
- Kidney Neoplasms
(immunology, therapy)
- Male
- Middle Aged
- Phenotype
- Prognosis
- Survival Analysis
- Thyroid Diseases
(etiology, immunology)
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