Effect of verapamil on QT interval dynamicity.

Abstract

Using measurements of QT/RR slopes with a computerized Holter system, QT interval dynamicity was evaluated in 19 patients with normal structural heart before and 2 months after oral treatment with verapamil prescribed for paroxysmal atrioventricular nodal reentrant tachycardia. Verapamil significantly shortened QT at low heart rates, mainly in the diurnal period, and this characteristic may explain, in part, the previously reported protective effect of verapamil against torsades de pointes.

• Authors: L Fauchier, D Babuty, P Poret, M L Autret, P Cosnay, J P Fauchier
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 83 Issue 5 Pg. 807-8, A10-1 (Mar 01 1999) ISSN: 0002-9149 [Print] United States
• PMID: 10080448 (Publication Type: Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Verapamil

Topics

• Administration, Oral
• Adult
• Aged
• Anti-Arrhythmia Agents (administration & dosage, therapeutic use)
• Circadian Rhythm
• Electrocardiography, Ambulatory (drug effects)
• Female
• Heart Rate (drug effects)
• Humans
• Male
• Middle Aged
• Tachycardia, Atrioventricular Nodal Reentry (drug therapy)
• Tachycardia, Paroxysmal (drug therapy)
• Torsades de Pointes (drug therapy)
• Verapamil (administration & dosage, therapeutic use)