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Short-term versus longer term pimozide therapy in Tourette's syndrome: a preliminary study.

Abstract
The authors randomized 10 patients (age range, 7 to 13 years) with Tourette's syndrome who had achieved a stable level of tic control on open-label pimozide to continue on pimozide (n = 6) or be withdrawn from therapy (n = 4) in a double-blind study. The median time to end point (the time when an increased dose of study medication was required to control tics) was 231 days (continued) versus 37 days (withdrawn), and the survival curves were significantly different (p = 0.02). Chronic, longer term treatment with pimozide appears to be more effective in controlling the course of tics than using the drug acutely to treat an exacerbation.
Authors
JournalNeurology (Neurology) Vol. 52 Issue 4 Pg. 874-7 (Mar 10 1999) ISSN: 0028-3878 [Print] UNITED STATES
PMID10078748 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Pimozide
Topics
  • Adolescent
  • Child
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Pilot Projects
  • Pimozide (therapeutic use)
  • Prospective Studies
  • Time Factors
  • Tourette Syndrome (drug therapy)

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