Autoradiographic evaluation of 99mTc-methylene diphosphonate accumulation in oral cancer invading the mandible.

Abstract

PURPOSE:

Skeletal scintigraphy, a sensitive diagnostic tool used to detect changes in bone, is helpful for evaluating bone invasion by oral cancer. However, the exact sites of accumulation of 99mTc-phosphate compounds in the mandible have not yet been fully elucidated. The aim of this study was to determine the localization of 99mTc-methylene diphosphonate (MDP) in the areas of mandible that have been invaded by cancer.

PATIENTS AND METHODS:

Seven patients with oral cancer (lower gingiva, 4; tongue, 2; floor of the mouth, 1) who underwent surgical treatment with mandibular bone resection were included in the study. Autoradiography and contact macroradiography were used for evaluation of 99mTc-MDP accumulation.

RESULTS:

Radioactivity reflecting accumulation of 99mTc-MDP was documented encircling the portion of the mandible with cancerous invasion, suggesting that 99mTc-MDP accumulated in immature bone. High uptake also was found in the periosteal reactive bone around the cortical bone.

CONCLUSIONS:

The amount of increased 99mTc-MDP circumscribing carcinoma invasion varies among cases. Additionally, uptake may not correspond directly with the amount of the carcinoma invasion; that seen in periosteal bone could be attributed mistakenly to bone invasion in planar scintigraphy.

• Authors: M Tsuchimochi, M Katagiri, K Maeda, J Kato
• Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 57 Issue 3 Pg. 245-54 (Mar 1999) ISSN: 0278-2391 [Print] United States
• PMID: 10077195 (Publication Type: Journal Article)

Chemical References

• Technetium Tc 99m Medronate

Topics

• Aged
• Alveolar Process (diagnostic imaging)
• Autoradiography
• Carcinoma, Adenoid Cystic (diagnostic imaging)
• Carcinoma, Squamous Cell (diagnostic imaging)
• Female
• Gingival Neoplasms (pathology)
• Humans
• Male
• Mandibular Neoplasms (diagnostic imaging)
• Middle Aged
• Mouth Floor (pathology)
• Neoplasm Invasiveness
• Radionuclide Imaging
• Technetium Tc 99m Medronate
• Tongue Neoplasms (pathology)