HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder.

Abstract
A genetic contribution to the pathogenesis of panic disorder has been demonstrated by clinical genetic studies. Molecular genetic studies have focused on candidate genes suggested by the molecular mechanisms implied in the action of drugs utilized for therapy or in challenge tests. One class of drugs effective in the treatment of panic disorder is represented by monoamine oxidase A inhibitors. Therefore, the monoamine oxidase A gene on chromosome X is a prime candidate gene. In the present study we investigated a novel repeat polymorphism in the promoter of the monoamine oxidase A gene for association with panic disorder in two independent samples (German sample, n = 80; Italian sample, n = 129). Two alleles (3 and 4 repeats) were most common and constituted >97% of the observed alleles. Functional characterization in a luciferase assay demonstrated that the longer alleles (3a, 4 and 5) were more active than allele 3. Among females of both the German and the Italian samples of panic disorder patients (combined, n = 209) the longer alleles (3a, 4 and 5) were significantly more frequent than among females of the corresponding control samples (combined, n = 190, chi2 = 10.27, df = 1, P = 0.001). Together with the observation that inhibition of monoamine oxidase A is clinically effective in the treatment of panic disorder these findings suggest that increased monoamine oxidase A activity is a risk factor for panic disorder in female patients.
AuthorsJ Deckert, M Catalano, Y V Syagailo, M Bosi, O Okladnova, D Di Bella, M M Nöthen, P Maffei, P Franke, J Fritze, W Maier, P Propping, H Beckmann, L Bellodi, K P Lesch
JournalHuman molecular genetics (Hum Mol Genet) Vol. 8 Issue 4 Pg. 621-4 (Apr 1999) ISSN: 0964-6906 [Print] ENGLAND
PMID10072430 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA, Recombinant
  • Luciferases
  • Monoamine Oxidase
Topics
  • Alleles
  • DNA, Recombinant (genetics, metabolism)
  • Data Interpretation, Statistical
  • Female
  • Gene Expression Regulation, Enzymologic
  • Gene Frequency
  • Genotype
  • Humans
  • Luciferases (genetics)
  • Male
  • Monoamine Oxidase (genetics)
  • Panic Disorder (genetics)
  • Polymorphism, Genetic
  • Promoter Regions, Genetic (genetics)
  • Sex Factors
  • Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: