Histone acetylases and deacetylases in cell proliferation.

Abstract

There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals their involvement in cell-cycle regulation and differentiation. Furthermore, accumulating evidence suggests that deregulation of acetylase and deacetylase activity plays a causative role in the generation of cancer.

• Authors: T Kouzarides
• Journal: Current opinion in genetics & development (Curr Opin Genet Dev) Vol. 9 Issue 1 Pg. 40-8 (Feb 1999) ISSN: 0959-437X [Print] England
• PMID: 10072350 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Saccharomyces cerevisiae Proteins
• Acetyltransferases
• Histone Acetyltransferases
• Histone Deacetylases

Topics

• Acetyltransferases (genetics, physiology)
• Animals
• Cell Division
• Gene Expression Regulation, Enzymologic
• Gene Expression Regulation, Neoplastic
• Histone Acetyltransferases
• Histone Deacetylases (genetics, physiology)
• Humans
• Neoplasms (enzymology, genetics)
• Saccharomyces cerevisiae Proteins