Danazol therapy in cyclic acquired amegakaryocytic thrombocytopenic purpura: a case report.

Cyclic acquired amegakaryocytic thrombocytopenic purpura (AATP) is a rare disorder characterized by periodic fluctuations in the platelet counts due to a defect in the platelet production. We describe a 42-year-old female with cyclic AATP, in whom the cyclic fluctuations in the platelet counts ceased with danazol therapy. The pathogenesis of the disease and the possible mechanisms of danazol action have been reviewed.
AuthorsR Kashyap, V P Choudhry, H P Pati
JournalAmerican journal of hematology (Am J Hematol) Vol. 60 Issue 3 Pg. 225-8 (Mar 1999) ISSN: 0361-8609 [Print] UNITED STATES
PMID10072115 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Estrogen Antagonists
  • Danazol
  • Adult
  • Danazol (administration & dosage)
  • Estrogen Antagonists (administration & dosage)
  • Female
  • Humans
  • Megakaryocytes (pathology)
  • Purpura, Thrombocytopenic (drug therapy, pathology, physiopathology)

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