Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma.

Occlusive vasculopathy is a potential complication of radiotherapy in children with optic pathway glioma. With a median follow-up of 7 years, 13 of 69 children in this study developed clinical and radiological signs of occlusive vasculopathy after radiotherapy within a median interval of 36 months. The major risk factor was neurofibromatosis type 1. Radiotherapy should no longer be the first treatment in these settings. When radiotherapy is unavoidable, regular screening for cerebral vasculopathy is mandatory, as preventive treatment is available.
AuthorsJ Grill, D Couanet, C Cappelli, J L Habrand, D Rodriguez, C Sainte-Rose, C Kalifa
JournalAnnals of neurology (Ann Neurol) Vol. 45 Issue 3 Pg. 393-6 (Mar 1999) ISSN: 0364-5134 [Print] UNITED STATES
PMID10072056 (Publication Type: Journal Article)
  • Cerebrovascular Disorders (etiology)
  • Child
  • Female
  • Glioma (complications, radiotherapy)
  • Humans
  • Male
  • Neurofibromatoses (complications, radiotherapy)
  • Optic Chiasm
  • Optic Nerve Neoplasms (complications, radiotherapy)
  • Radiotherapy (adverse effects)

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