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Lacidipine prevents the hypertension and renal and cardiac changes induced by high-fructose diet in WKY rats.

Abstract
Normotensive rats fed a high-fructose diet (HFD) develop hypertriglyceridemia, hyperinsulinemia, and hypertension. The glomerular changes observed in the kidneys of these animals are similar to those observed in diabetic rats. The aim of this study was to evaluate whether lacidipine, a calcium antagonist, could have a protective effect with this animal model. Forty male Wistar-Kyoto (WKY) rats were divided into four groups treated with HFD + placebo; HFD + lacidipine, 0.3 mg/kg/day; HFD + lacidipine, 3 mg/kg/day; or standard diet + placebo for 4 weeks. Urinary excretion of the stable metabolic products of nitric oxide (NO) was determined, because this vasoactive agent has been found to cause hemodynamic changes in the diabetic kidney. Glomerular size was determined by means of morphometric analysis. The results of this study show that lacidipine prevents (a) the HFD-induced increase in blood pressure in a dose-dependent manner; (b) the HFD-induced increase in glomerular size and fibronectin synthesis; and (c) the increase of collagen III synthesis in the heart. The drug had no effect on the increased urinary excretion of the stable metabolic products of NO. These data suggest that lacidipine might be useful in preventing the renal and cardiac damage caused by hypertension and non-insulin-dependent diabetes mellitus.
AuthorsA Cosenzi, A Sacerdote, P Seculin, G Odoni, N Plazzotta, E Bernobich, G Bellini
JournalJournal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 33 Issue 3 Pg. 485-91 (Mar 1999) ISSN: 0160-2446 [Print] United States
PMID10069686 (Publication Type: Journal Article)
Chemical References
  • Antihypertensive Agents
  • Blood Glucose
  • Dietary Carbohydrates
  • Dihydropyridines
  • Fibronectins
  • Insulin
  • Triglycerides
  • lacidipine
  • Fructose
  • Nitric Oxide
  • Collagen
  • Creatinine
Topics
  • Animals
  • Antihypertensive Agents (pharmacology, therapeutic use)
  • Blood Glucose (drug effects)
  • Blood Pressure (drug effects)
  • Body Weight (drug effects)
  • Collagen (drug effects, metabolism)
  • Creatinine (blood)
  • Dietary Carbohydrates (administration & dosage, adverse effects)
  • Dihydropyridines (pharmacology, therapeutic use)
  • Dose-Response Relationship, Drug
  • Fibronectins (drug effects, metabolism)
  • Fructose (administration & dosage, adverse effects)
  • Heart Diseases (chemically induced, pathology, prevention & control)
  • Hypertension (chemically induced, prevention & control)
  • Insulin (blood)
  • Kidney (drug effects, metabolism, pathology)
  • Kidney Diseases (chemically induced, pathology, prevention & control)
  • Kidney Glomerulus (drug effects, pathology)
  • Male
  • Myocardium (metabolism, pathology)
  • Nitric Oxide (urine)
  • Organ Size (drug effects)
  • Rats
  • Rats, Inbred WKY
  • Triglycerides (blood)

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