Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: Both supplementation schemes reduced homocysteine to a similar extent (35%) but did not normalize homocysteine concentrations in the majority of patients. Dialysis also had a strong homocysteine lowering effect. After supplementation, 74% of the hemodialysis patients had post-dialysis homocysteine concentrations within the reference range (<16 micromol/l). Homocysteine concentrations remained decreased in 20 patients four weeks after withdrawal of folic acid supplementation. CONCLUSIONS: It is concluded that supplementation with 2.5 or 5 mg folic acid has a similar effect on homocysteine concentrations to supplementation regimens using 15 mg folic acid supplements. In contrast to the effect of folic acid supplementation in subjects with normal renal function, folic acid supplementation does not normalize homocysteine concentrations in ESRD patients.
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Authors | J Dierkes, U Domröse, A Ambrosch, H P Bosselmann, K H Neumann, C Luley |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 51
Issue 2
Pg. 108-15
(Feb 1999)
ISSN: 0301-0430 [Print] Germany |
PMID | 10069646
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Erythrocytes
(metabolism)
- Folic Acid
(administration & dosage)
- Genotype
- Homocysteine
(blood)
- Humans
- Hyperhomocysteinemia
(blood, drug therapy, genetics)
- Kidney Failure, Chronic
(blood, therapy)
- Middle Aged
- Peritoneal Dialysis
- Renal Dialysis
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