HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Autoantibodies against M2 muscarinic receptors in patients with cardiomyopathy display non-desensitized agonist-like effects.

Abstract
Circulating autoantibodies against the human M2 muscarinic receptors have been previously shown in 38% of patients with idiopathic dilated cardiomyopathy. The functional properties of these autoantibodies are reported herein. They were able to decrease the cell beating frequency of myocytes in cultured neonatal rat heart cells in a dose-dependent manner without desensitization over a period of more than 5 hours whereas the non-specific muscarinic receptor agonist carbachol also inhibited the heart cell beating frequency but was desensitized within 1 hour. In the same cell culture, anti-M2 muscarinic receptor autoantibodies were not able to induce internalization of muscarinic receptor whereas carbachol did. These results demonstrate for the first time that anti-M2 muscarinic receptor autoantibodies from patients with idiopathic dilated cardiomyopathy have stimulatory muscarinic activity in vitro, which differ from normal muscarinic agonists by non-desensitization.
AuthorsG Wallukat, H M Fu, S Matsui, A Hjalmarson, M L Fu
JournalLife sciences (Life Sci) Vol. 64 Issue 6-7 Pg. 465-9 ( 1999) ISSN: 0024-3205 [Print] Netherlands
PMID10069511 (Publication Type: Journal Article)
Chemical References
  • Autoantibodies
  • Muscarinic Agonists
  • Muscarinic Antagonists
  • Receptor, Muscarinic M2
  • Receptors, Muscarinic
  • Atropine
  • Carbachol
  • N-Methylscopolamine
Topics
  • Animals
  • Atropine (pharmacology)
  • Autoantibodies (blood, isolation & purification, pharmacology, physiology)
  • Binding Sites (drug effects)
  • Carbachol (metabolism, pharmacology)
  • Cardiomyopathy, Dilated (blood, immunology, physiopathology)
  • Cells, Cultured
  • Depression, Chemical
  • Dose-Response Relationship, Drug
  • Down-Regulation (drug effects)
  • Heart Rate (drug effects)
  • Humans
  • Muscarinic Agonists (pharmacology)
  • Muscarinic Antagonists (pharmacology)
  • Myocardium (cytology)
  • N-Methylscopolamine (metabolism)
  • Rats
  • Rats, Wistar
  • Receptor, Muscarinic M2
  • Receptors, Muscarinic (immunology, metabolism)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: