Quinone analogue irrecoverably paralyses the filarial parasites in vitro.

Abstract

2,3-Dimethoxy-5-methyl-1,4-benzoquinone (Q0), an analogue of ubiquinone, irreversibly paralyses the adult and microfilariae of the cattle filarial parasite Setaria digitata. The same concentration of Q0 that paralyses the microfilariae of S. digitata also paralyses the microfilariae of the human filarial parasite Wuchereria bancrofti within the same duration. Thus the experiments done in the model S. digitata system can well be extended to the human filarial system. A drug at the level of the quinone-centered energy generating system, perhaps an analogue of quinone like Q0, can inactivate the filarial parasites and may prove to be an effective drug to control filariasis.

• Authors: V M Sivan, R Kaleysa Raj
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 256 Issue 1 Pg. 81-3 (Mar 05 1999) ISSN: 0006-291X [Print] United States
• PMID: 10066426 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 1999 Academic Press.

Chemical References

• Benzoquinones
• Fumarates
• Malates
• NAD
• ubiquinone-O
• malic acid
• fumaric acid
• Glucose
• Sodium Lactate

Topics

• Animals
• Benzoquinones (pharmacology, therapeutic use)
• Cattle
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Electron Transport (drug effects)
• Filariasis (drug therapy, parasitology)
• Fumarates (metabolism)
• Glucose (metabolism)
• Humans
• Malates (metabolism)
• Movement (drug effects)
• NAD (metabolism)
• Setaria Nematode (drug effects, physiology)
• Setariasis (drug therapy, parasitology)
• Sodium Lactate (metabolism)
• Time Factors
• Wuchereria bancrofti (drug effects, physiology)