Abstract |
A recent report suggested that barakol, a biologically active extract of the south-east Asian plant, Cassia siamea, has anxiolytic properties. The purpose of the present study was to replicate and extend these findings by examining the dose-response effects of barakol (0-20 mg/kg) in two pharmacologically validated tests of rat anxiety: the elevated plus-maze and the shock-probe burying tests. Although the purity of our sample of barakol was confirmed by chemical analysis, we found no evidence of its anxiolytic effects in either the plus-maze or shock-probe burying tests.
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Authors | D F Fiorino, D Treit, J Menard, L Lermer, A G Phillips |
Journal | Behavioural pharmacology
(Behav Pharmacol)
Vol. 9
Issue 4
Pg. 375-8
(Jul 1998)
ISSN: 0955-8810 [Print] England |
PMID | 10065927
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Anxiety Agents
- Benzopyrans
- Phenalenes
- barakol
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Topics |
- Analysis of Variance
- Animals
- Anti-Anxiety Agents
(pharmacology)
- Anxiety
(drug therapy)
- Benzopyrans
(pharmacology)
- Disease Models, Animal
- Electroshock
(adverse effects)
- Escape Reaction
(drug effects)
- Exploratory Behavior
(drug effects)
- Male
- Maze Learning
(drug effects)
- Motor Activity
(drug effects)
- Phenalenes
- Rats
- Rats, Sprague-Dawley
- Single-Blind Method
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