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Is barakol anxiolytic?

Abstract
A recent report suggested that barakol, a biologically active extract of the south-east Asian plant, Cassia siamea, has anxiolytic properties. The purpose of the present study was to replicate and extend these findings by examining the dose-response effects of barakol (0-20 mg/kg) in two pharmacologically validated tests of rat anxiety: the elevated plus-maze and the shock-probe burying tests. Although the purity of our sample of barakol was confirmed by chemical analysis, we found no evidence of its anxiolytic effects in either the plus-maze or shock-probe burying tests.
AuthorsD F Fiorino, D Treit, J Menard, L Lermer, A G Phillips
JournalBehavioural pharmacology (Behav Pharmacol) Vol. 9 Issue 4 Pg. 375-8 (Jul 1998) ISSN: 0955-8810 [Print] England
PMID10065927 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Anxiety Agents
  • Benzopyrans
  • Phenalenes
  • barakol
Topics
  • Analysis of Variance
  • Animals
  • Anti-Anxiety Agents (pharmacology)
  • Anxiety (drug therapy)
  • Benzopyrans (pharmacology)
  • Disease Models, Animal
  • Electroshock (adverse effects)
  • Escape Reaction (drug effects)
  • Exploratory Behavior (drug effects)
  • Male
  • Maze Learning (drug effects)
  • Motor Activity (drug effects)
  • Phenalenes
  • Rats
  • Rats, Sprague-Dawley
  • Single-Blind Method

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