Abstract | OBJECTIVE: METHODS:
IGFBP-1 concentrations were measured on 42 paired cervicovaginal samples before and after membrane rupture, using an immunoenzymatic assay. A PROM test [dipstick detecting IGFBP-1 with a cutoff value of 25 micrograms/l (A)], a BTB test (B), a ROM-Check (C), and a fern test (D) were compared in diagnosing ruptures of the membranes in 48 patients. RESULTS: The optimal cutoff concentration was between 20.1 micrograms/l and 148.4 micrograms/l by receiver operating characteristic curve analysis. The PROM test had the highest sensitivity (94.7%) and highest specificity (93.3%) (sensitivity of A-D, B-D, C-D and specificity of A-B: p < 0.05 by chi 2-test). Unlike the other tests, the PROM test is unaffected by contamination, cervical dilatation, or uterine contraction. CONCLUSIONS: The measurement of IGFBP-1 in vaginal fluids is useful for the diagnosis of ruptured fetal membranes.
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Authors | T Kubota, H Takeuchi |
Journal | The journal of obstetrics and gynaecology research
(J Obstet Gynaecol Res)
Vol. 24
Issue 6
Pg. 411-7
(Dec 1998)
ISSN: 1341-8076 [Print] Australia |
PMID | 10063236
(Publication Type: Journal Article)
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Chemical References |
- Insulin-Like Growth Factor Binding Protein 1
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Topics |
- Female
- Fetal Membranes, Premature Rupture
(diagnosis)
- Gestational Age
- Humans
- Insulin-Like Growth Factor Binding Protein 1
(blood)
- Predictive Value of Tests
- Pregnancy
- ROC Curve
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