Comparison of healing process in open osteotomy model and closed fracture model.

Abstract

OBJECTIVE:

Comparison of the healing process in open osteotomy and closed fracture models that were used to study fracture healing.

DESIGN:

Randomized, prospective study in experimental animals, with a recovery duration of two and four weeks.

SETTING:

Unrestricted cage activity with weight bearing as tolerated.

ANIMALS:

Thirty-four skeletally mature, female New Zealand White rabbits.

INTERVENTIONS:

Closed fractures and open osteotomies of the tibial diaphysis were reduced and immobilized with four-pin, double-bar external fixators.

MAIN OUTCOME MEASUREMENTS:

Callus circumference was measured with a tape measure, bridging callus was assessed on biplane radiographs and evaluated histologically, and torsional stiffness and maximum torque were measured.

RESULTS:

Periosteum damage was more severe and hematoma formation was smaller in the osteotomy model, resulting in a delay in biological healing and restoration of the biomechanical properties.

CONCLUSIONS:

Investigators should consider the difference between the closed fracture and open osteotomy models when selecting an animal model to investigate fracture healing.

• Authors: S H Park, K O'Connor, R Sung, H McKellop, A Sarmiento
• Journal: Journal of orthopaedic trauma (J Orthop Trauma) Vol. 13 Issue 2 Pg. 114-20 (Feb 1999) ISSN: 0890-5339 [Print] United States
• PMID: 10052786 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Bony Callus (pathology)
• Disease Models, Animal
• Female
• Fracture Fixation, Internal
• Fracture Healing (physiology)
• Fractures, Closed (pathology, surgery)
• Osteotomy
• Prospective Studies
• Rabbits
• Random Allocation
• Tibial Fractures (pathology, surgery)