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Decreased formation of ethoxyacetic acid from ethylene glycol monoethyl ether and reduced atrophy of testes in male rats upon combined administration with toluene and xylene.

Abstract
Male painters are commonly exposed to ethylene glycol monoethyl ether (EGE), a well known reproductive toxic agent causing testicular atrophy, in the form of solvent mixture containing toluene (TOL) and xylene (XYL). This study was carried out to determine the effect of exposing male rats to solvent mixture containing TOL and XYL on the EGE (200 mg/kg) on testicular atrophy and production of toxic metabolite, ethoxyacetic acid (EAA) from EGE. Compared to the extent of testes atrophy observed upon EGE administration alone, the combined administration of EGE (200 mg/kg) with TOL (250 mg/kg) and XYL (500 mg/kg) for 4 weeks has reduced the extent of testes atrophy by 25%. The combined administration delayed the time for appearance of the highest plasma concentration (t(max)) of EAA from 3 to 6 h and also decreased the highest concentration (Cmax) as well as the total amount of plasma EAA (AUC(0-18 h)) by 45 and 29%, respectively. This explained the diminished testicular atrophy in male rats observed when EGE was administered in a solvent mixture containing TOL and XYL. This study suggested that testicular toxicity observed in male painters caused by EGE may be decreased when they are exposed to EGE in the form of solvent mixture containing TOL and XYL.
AuthorsW G Chung, I J Yu, C S Park, K H Lee, H K Roh, Y N Cha
JournalToxicology letters (Toxicol Lett) Vol. 104 Issue 1-2 Pg. 143-50 (Jan 11 1999) ISSN: 0378-4274 [Print] Netherlands
PMID10048760 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acetates
  • Ethylene Glycols
  • Solvents
  • Xylenes
  • Toluene
  • ethoxyacetic acid
  • 2-ethoxyethanol
Topics
  • Acetates (blood, metabolism)
  • Animals
  • Atrophy
  • Ethylene Glycols (pharmacokinetics, toxicity)
  • Kinetics
  • Male
  • Organ Size (drug effects)
  • Rats
  • Rats, Sprague-Dawley
  • Solvents (pharmacology, toxicity)
  • Testicular Diseases (chemically induced, pathology)
  • Testis (drug effects, pathology)
  • Toluene (pharmacology, toxicity)
  • Xylenes (pharmacology, toxicity)

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