Induction of sister chromatid exchanges and chromosome aberrations in vivo in Etroplus suratensis (Bloch) following exposure to organophosphorus pesticides.

Abstract

The genotoxic potential of methyl parathion and phosphamidon, two commercial formulations of organophosphorus pesticides, was evaluated through induction of sister chromatid exchanges (SCE) and chromosome aberrations in fish gill tissues. Fishes exposed to the medium containing 0.05, 0.1 and 0.2 ppm of methyl parathion or 0.5, 1.0, and 2.0 ppm of phosphamidon for a duration of 96 h revealed significant increase in the number of SCE and chromosome aberrations against control values. This demonstrates the feasibility of the fish in vivo system in detecting genotoxic potential of pollutants.

• Authors: P Das, G John
• Journal: Toxicology letters (Toxicol Lett) Vol. 104 Issue 1-2 Pg. 111-6 (Jan 11 1999) ISSN: 0378-4274 [Print] Netherlands
• PMID: 10048756 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insecticides
• Water Pollutants, Chemical
• Phosphamidon
• Methyl Parathion

Topics

• Animals
• Chromosome Aberrations (genetics)
• Gills (cytology, drug effects)
• Insecticides (toxicity)
• Karyotyping
• Metaphase (drug effects)
• Methyl Parathion (toxicity)
• Perches (physiology)
• Phosphamidon (toxicity)
• Sister Chromatid Exchange (drug effects)
• Water Pollutants, Chemical (toxicity)