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Posterior vitreous detachment induced by injection of plasmin and sulfur hexafluoride in the rabbit vitreous.

AbstractPURPOSE:
To investigate whether an injection of plasmin and sulfur hexafluoride (SF6) can induce posterior vitreous detachment (PVD) without vitrectomy.
METHODS:
One eye each of 15 New Zealand white rabbits was assigned to one of three groups. Eyes in group 1 received a vitreous injection of 1 unit of human plasmin (0.1 mL reconstituted in balanced salt solution) and 0.5 mL of SF6; eyes in group 2 received a vitreous injection of plasmin alone; eyes in group 3 received a vitreous injection of SF6 alone. Seven days after injection, all animals were monitored electroretinographically and killed, and the eyes were enucleated. After fixation, scanning electron microscopy was performed.
RESULTS:
In group 1 eyes, the retinal surface was smooth except for the vitreous base, which showed complete separation of the vitreous cortex from the retina, indicating PVD. In group 2 and 3 eyes, sparse collagen fibers remained on the retinal surface.
CONCLUSION:
Vitreous injection of plasmin combined with SF6 can induce PVD without vitrectomy.
AuthorsT Hikichi, N Yanagiya, M Kado, J Akiba, A Yoshida
JournalRetina (Philadelphia, Pa.) (Retina) Vol. 19 Issue 1 Pg. 55-8 ( 1999) ISSN: 0275-004X [Print] United States
PMID10048374 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fibrinolysin
  • Sulfur Hexafluoride
Topics
  • Animals
  • Drug Therapy, Combination
  • Electroretinography
  • Eye Diseases (pathology, surgery)
  • Fibrinolysin (administration & dosage)
  • Injections
  • Male
  • Microscopy, Electron, Scanning
  • Ophthalmologic Surgical Procedures (methods)
  • Rabbits
  • Retina (physiology)
  • Sulfur Hexafluoride (administration & dosage)
  • Vitreous Body (drug effects, surgery, ultrastructure)

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