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Nasal administration of recombinant rat IL-4 ameliorates ongoing experimental autoimmune neuritis and inhibits demyelination.

Abstract
Experimental autoimmune neuritis (EAN) is a CD4(+)T cell-mediated demyelinating disease of the peripheral nervous system (PNS) and serves as an experimental model for human immune-demyelinating neuropathies. In this study, we examined the effect of recombinant rat interleukin-4 (rrIL-4) on chronic EAN in Lewis rats induced by immunization with P0 peptide 180-199 and complete Freund's adjuvant (CFA). We estimated that nasal administration of rrIL-4, in dose ranges of 0.1-1 microg/rat/day in the initial phase of EAN, decreased the severity and the duration of clinical EAN. Hyporesponsiveness of T cells, downregulation of Th1 cell responses (INF-gamma), but increased levels of specific IgG1 isotypes document that nasal administration of rrIL-4 was systemically immune effective. Low grade inflammation and complete lack of regional demyelination within the sciatic nerves were seen in rrIL-4 treated rats. Based on these observations we suggest that nasal administration of IL-4 could be further evaluated, considering its possible use in human immune-demyelinating neuropathies.
AuthorsG Deretzi, L P Zou, S H Pelidou, I Nennesmo, M Levi, B Wahren, E Mix, J Zhu
JournalJournal of autoimmunity (J Autoimmun) Vol. 12 Issue 2 Pg. 81-9 (Mar 1999) ISSN: 0896-8411 [Print] England
PMID10047428 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 1999 Academic Press.
Chemical References
  • Immunoglobulin G
  • Recombinant Proteins
  • Interleukin-4
  • Interferon-gamma
Topics
  • Administration, Intranasal
  • Animals
  • Autoimmune Diseases (immunology, pathology, therapy)
  • Demyelinating Diseases (immunology, pathology, therapy)
  • Disease Models, Animal
  • Humans
  • Immunoglobulin G (blood, classification)
  • Interferon-gamma (metabolism)
  • Interleukin-4 (administration & dosage)
  • Lymphocyte Activation
  • Male
  • Neuritis (immunology, pathology, therapy)
  • Rats
  • Rats, Inbred Lew
  • Recombinant Proteins (administration & dosage)

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