Association of plasma triglyceride-rich lipoprotein remnants with coronary atherosclerosis in cases of sudden cardiac death.

Abstract

Among the risk factors for coronary atherosclerosis, elevated LDL-C level is best known. The action of lipoprotein lipase on triglyceride-rich lipoproteins produces remnant lipoprotein particles enriched in cholesterol and apolipoprotein E (apo E). Apo E serves as the ligand for uptake of remnant lipoproteins via the LDL-receptor or the remnant receptor. In this study, postmortem plasma total cholesterol, triglycerides (TG), VLDL-C, HDL-C, lipoprotein (a) [Lp(a)] and remnant-like lipoprotein particles (RLP)-cholesterol, RLP-TG, apolipoproteins B, C III and E were measured, together with LDL-C to assess their potential contribution to the severity of coronary and aortic atherosclerosis of the 197 cases of sudden death (132 cardiac death and 65 non-cardiac death). In all cases, the severity of coronary atherosclerosis was determined at postmortem pathological examination. RLP-cholesterol (RLP-C) and LDL-C concentrations were significantly higher in cases with advanced coronary atherosclerosis compared with those without coronary atherosclerosis; respective median values were 13.5 vs 8.4 mg/dl (P < 0.001) and 140 vs 115 mg/dl (P < 0.05). RLP-C levels were more strongly correlated with the severity score of coronary atherosclerosis than LDL-C.

• Authors: S Takeichi, N Yukawa, Y Nakajima, M Osawa, T Saito, Y Seto, T Nakano, A R Saniabadi, M Adachi, T Wang, K Nakajima
• Journal: Atherosclerosis (Atherosclerosis) Vol. 142 Issue 2 Pg. 309-15 (Feb 1999) ISSN: 0021-9150 [Print] Ireland
• PMID: 10030382 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Apolipoproteins
• Biomarkers
• Cholesterol, HDL
• Cholesterol, LDL
• Cholesterol, VLDL
• Lipoprotein(a)
• Lipoproteins
• Triglycerides
• lipoprotein triglyceride
• remnant-like particle cholesterol
• Cholesterol

Topics

• Adult
• Aged
• Apolipoproteins (blood)
• Biomarkers (blood)
• Cholesterol
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Cholesterol, VLDL (blood)
• Chromatography, High Pressure Liquid
• Coronary Artery Disease (blood, mortality, pathology)
• Death, Sudden, Cardiac (pathology)
• Female
• Humans
• Lipoprotein(a) (blood)
• Lipoproteins (blood)
• Male
• Middle Aged
• Nephelometry and Turbidimetry
• Retrospective Studies
• Severity of Illness Index
• Triglycerides (blood)