Abstract |
Among the risk factors for coronary atherosclerosis, elevated LDL-C level is best known. The action of lipoprotein lipase on triglyceride-rich lipoproteins produces remnant lipoprotein particles enriched in cholesterol and apolipoprotein E ( apo E). Apo E serves as the ligand for uptake of remnant lipoproteins via the LDL-receptor or the remnant receptor. In this study, postmortem plasma total cholesterol, triglycerides (TG), VLDL-C, HDL-C, lipoprotein (a) [Lp(a)] and remnant-like lipoprotein particles (RLP)- cholesterol, RLP-TG, apolipoproteins B, C III and E were measured, together with LDL-C to assess their potential contribution to the severity of coronary and aortic atherosclerosis of the 197 cases of sudden death (132 cardiac death and 65 non- cardiac death). In all cases, the severity of coronary atherosclerosis was determined at postmortem pathological examination. RLP- cholesterol (RLP-C) and LDL-C concentrations were significantly higher in cases with advanced coronary atherosclerosis compared with those without coronary atherosclerosis; respective median values were 13.5 vs 8.4 mg/dl (P < 0.001) and 140 vs 115 mg/dl (P < 0.05). RLP-C levels were more strongly correlated with the severity score of coronary atherosclerosis than LDL-C.
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Authors | S Takeichi, N Yukawa, Y Nakajima, M Osawa, T Saito, Y Seto, T Nakano, A R Saniabadi, M Adachi, T Wang, K Nakajima |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 142
Issue 2
Pg. 309-15
(Feb 1999)
ISSN: 0021-9150 [Print] Ireland |
PMID | 10030382
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Apolipoproteins
- Biomarkers
- Cholesterol, HDL
- Cholesterol, LDL
- Cholesterol, VLDL
- Lipoprotein(a)
- Lipoproteins
- Triglycerides
- lipoprotein triglyceride
- remnant-like particle cholesterol
- Cholesterol
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Topics |
- Adult
- Aged
- Apolipoproteins
(blood)
- Biomarkers
(blood)
- Cholesterol
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Cholesterol, VLDL
(blood)
- Chromatography, High Pressure Liquid
- Coronary Artery Disease
(blood, mortality, pathology)
- Death, Sudden, Cardiac
(pathology)
- Female
- Humans
- Lipoprotein(a)
(blood)
- Lipoproteins
(blood)
- Male
- Middle Aged
- Nephelometry and Turbidimetry
- Retrospective Studies
- Severity of Illness Index
- Triglycerides
(blood)
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