Abstract | BACKGROUND: METHODS: RESULTS: Nephrotic subjects ( albumin 23 +/- 2 g/liter and LDL cholesterol 3.1 +/- 0.2 mmol/liter) had a LDL LPC concentration that was increased (P < 0.05) to 66 +/- 7 vs. 35 +/- 6 micromol/liter in matched controls ( albumin 42 +/- 5 g/liter and LDL cholesterol 3.1 +/- 0.2 mmol/liter). LPC in very low-density lipoprotein plus intermediate-density lipoprotein (VLDL + IDL) in these subjects was also increased to 33 +/- 7 vs. 9 +/- 2 micromol/liter in controls (P < 0.05). Conversely, LPC was decreased to 19 +/- 4 micromol/liter in the albumin-containing fraction of these hypoalbuminemic patients, as compared to 46 +/- 10 micromol/liter in the controls (P < 0.05). LPC was also low (14 +/- 4 micromol/liter) in the albumin-containing fraction of hypoalbuminemic, hypocholesterolemic patients with nonrenal diseases. In hyperlipidemic nephrotic subjects ( albumin 21 +/- 2 g/liter and LDL cholesterol 5.7 +/- 0.5 mmol/liter) the LPC levels in LDL and VLDL + IDL were further increased, to 95 +/- 20 and 56 +/- 23 micromol/liter, respectively (P < 0.05). CONCLUSION:
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Authors | T D Vuong, E S Stroes, N Willekes-Koolschijn, T J Rabelink, H A Koomans, J A Joles |
Journal | Kidney international
(Kidney Int)
Vol. 55
Issue 3
Pg. 1005-10
(Mar 1999)
ISSN: 0085-2538 [Print] United States |
PMID | 10027937
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lipoproteins
- Lipoproteins, IDL
- Lipoproteins, LDL
- Lipoproteins, VLDL
- Lysophosphatidylcholines
- Serum Albumin
- Cholesterol
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Topics |
- Adolescent
- Adult
- Aged
- Cardiovascular Diseases
(etiology)
- Case-Control Studies
- Cholesterol
(blood)
- Female
- Humans
- Hyperlipidemias
(blood, complications)
- Lipoproteins
(blood, chemistry)
- Lipoproteins, IDL
- Lipoproteins, LDL
(blood, chemistry)
- Lipoproteins, VLDL
(blood, chemistry)
- Lysophosphatidylcholines
(blood)
- Male
- Middle Aged
- Nephrotic Syndrome
(blood, complications)
- Protein Binding
- Serum Albumin
(deficiency)
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