Proton-Coupled Folate Transporter

A symporter protein that couples the transport of FOLIC ACID with HYDROGEN IONS. The transporter functions most effectively under acidic conditions.
Also Known As:
Folate Transporter, Proton-Coupled; Solute Carrier Family 46, Member 1; Folate Transporter, Proton Coupled; Proton Coupled Folate Transporter; Transporter, Proton-Coupled Folate
Networked: 18 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results


1. Matherly, Larry H: 10 articles (09/2015 - 10/2010)
2. Hou, Zhanjun: 9 articles (09/2015 - 10/2010)
3. Gangjee, Aleem: 8 articles (09/2015 - 10/2010)
4. Cherian, Christina: 7 articles (04/2013 - 10/2010)
5. Wang, Lei: 6 articles (09/2015 - 10/2011)
6. White, Kathryn: 5 articles (09/2015 - 10/2011)
7. Kushner, Juiwanna: 5 articles (09/2015 - 10/2011)
8. Polin, Lisa: 5 articles (09/2015 - 10/2011)
9. Stout, Mark: 5 articles (04/2013 - 10/2010)
10. Desmoulin, Sita Kugel: 4 articles (12/2012 - 10/2010)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
08/01/2014 - "Breast Cancer Resistance Protein (BCRP), Multidrug Resistance Proteins (MRP), P-glycoprotein (P-gp), Organic Anion Transporters (OATs), Organic Anion Transporting Polypeptides (OATPs), Organic Cation Transporters (OCTs), Peptide Transport Proteins (PepTs), Human Proton-Coupled Folate Transporter (PCFT) and Multidrug and Toxic Extrusion Proteins (MATEs), have been reported to exhibit either positive or negative enantio-selective substrate recognition. "
01/01/2008 - "These mechanisms of adaptation to folate deficiency generally associated with folate uptake, intracellular folate retention, folate-dependent metabolism, and active folate efflux specifically include: (a) Up- or downregulation of various folate-dependent enzymes like dihydrofolate reductase (DHFR) and thymidylate synthase (TS), (b) Cellular retention of folates via polyglutamylation by the enzyme folylpoly-gamma-glutamate synthetase (FPGS), (c) Overexpression of folate influx systems including the reduced folate carrier (RFC), folate receptor (FR) as well as the proton-coupled folate transporter (PCFT), a recently identified intestinal folate influx transporter optimally functioning at the acidic microclimate of the upper intestinal epithelium, (d) Downregulation of ATP-driven folate efflux transporters of the multidrug resistance protein (MRP; ABCC) family and breast cancer resistance protein (BCRP; ABCG2) that belong to the multidrug resistance (MDR) efflux transporters of the ATP-binding cassette (ABC) superfamily. "
3. Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
4. Psoriasis (Pustulosis Palmaris et Plantaris)
5. Pre-Eclampsia (Preeclampsia)

Related Drugs and Biologics

1. Folic Acid (Vitamin M)
2. pyrimidine
3. Folic Acid Antagonists
4. Protons (Proton)
5. Reduced Folate Carrier Protein
6. Folate Receptor 2
7. Organic Anion Transporters
8. P-Glycoprotein
9. Glutamic Acid (Glutamate)
10. P-Glycoproteins

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)