|1.||Assaraf, Yehuda G: 9 articles (01/2008 - 03/2003)|
|2.||Matherly, Larry H: 8 articles (09/2015 - 02/2004)|
|3.||Goldman, I David: 7 articles (03/2007 - 11/2002)|
|4.||Li, Zhu: 7 articles (05/2006 - 03/2004)|
|5.||Zhu, Huiping: 6 articles (01/2015 - 02/2002)|
|6.||Gorlick, Richard: 6 articles (01/2011 - 02/2003)|
|7.||Finnell, Richard H: 6 articles (08/2009 - 02/2002)|
|8.||Zhao, Rongbao: 6 articles (03/2007 - 11/2002)|
|9.||Ifergan, Ilan: 5 articles (01/2008 - 11/2003)|
|10.||Matherly, L H: 5 articles (01/2003 - 01/2001)|
09/10/2015 - "The selectivity of these compounds for PCFT and for FRα and β over the ubiquitously expressed reduced folate carrier is a paradigm for selective tumor targeting. "
02/11/2010 - "Sonogashira coupling with (S)-2-[(5-bromo-thiophene-2-carbonyl)-amino]-pentanedioic acid diethyl ester, followed by hydrogenation and saponification, afforded 1-3. Compounds 1 and 2 potently inhibited KB and IGROV1 human tumor cells that express FR alpha, reduced folate carrier (RFC), and PCFT. "
04/01/2008 - "Other mechanisms to explain the role of reduced folate carrier in cancer."
03/01/2007 - "Human reduced folate carrier: translation of basic biology to cancer etiology and therapy."
12/01/2006 - "Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a Chinese population."
|2.||Osteosarcoma (Osteogenic Sarcoma)
01/01/2014 - "In this study, the relationship between reduced folate carrier (RFC) gene expression and intracellular drug concentration in MTX-resistant osteosarcoma cells (Saos-2) was investigated. "
05/01/2009 - "DHFR and Reduced folate carrier 1 (RFC1) semiquantitative expression was analyzed in 34 primary and metastatic osteosarcoma tissues by real-time polymerase chain reaction. "
09/01/2008 - "Polymorphisms and methylation of the reduced folate carrier in osteosarcoma."
10/14/2004 - "Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas."
02/01/2003 - "Decreased reduced folate carrier (RFC) expression has been shown in approximately half of osteosarcomas at diagnosis. "
05/01/2002 - "Gene-expression analysis revealed prominent expression of the folate receptor in some but not all mesothelioma cell lines, and in only one case was expression of this receptor gene greater than expression of the reduced folate carrier gene. "
02/01/2006 - "Pemetrexed, a new generation antifolate recently approved for the treatment of mesothelioma and non-small cell lung cancer, is an excellent substrate for the reduced folate carrier (RFC). "
05/01/2002 - "As a response to a published report documenting some expression of folate receptor alpha in human mesothelioma, studies were carried out examining the role of this receptor versus that of the reduced folate carrier in the internalization of folate analogs in this neoplasm. "
05/01/2002 - "In view of the ongoing reduced folate carrier-mediated internalization that occurs in mesothelioma cells, these results would seem to argue against a role for the folate receptor in the internalization and cellular pharmacokinetics of methotrexate and other classic folate analogs in this neoplasm. "
04/01/2013 - "We examined whether the novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate, compound 2, might be an effective treatment for malignant pleural mesothelioma (MPM), reflecting its selective membrane transport by the proton-coupled folate transport (PCFT) over the reduced folate carrier (RFC). "
06/01/2015 - "Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis."
01/01/2013 - "A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis."
11/01/2004 - "Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis."
07/01/2004 - "To investigate whether interactions of sulfasalazine (SSZ) with reduced folate carrier (RFC), the dominant cell membrane transporter for natural folates and methotrexate (MTX), may limit the efficacy of combination therapy with MTX and SSZ in patients with rheumatoid arthritis. "
07/01/2004 - "Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis."
|1.||Folic Acid (Vitamin M)
|3.||Folic Acid Antagonists
|8.||Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
|9.||Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
|1.||Drug Therapy (Chemotherapy)