|1.||O'Shannessy, Daniel J: 9 articles (01/2015 - 12/2011)|
|2.||Low, Philip S: 8 articles (06/2015 - 09/2006)|
|3.||Somers, Elizabeth B: 7 articles (01/2015 - 12/2011)|
|4.||Kelemen, Linda E: 5 articles (01/2014 - 09/2005)|
|5.||Coleman, Robert L: 4 articles (01/2015 - 03/2010)|
|6.||Kalli, Kimberly R: 4 articles (01/2009 - 09/2006)|
|7.||Murphy, Linda: 3 articles (06/2015 - 04/2008)|
|8.||Armstrong, Deborah K: 3 articles (11/2013 - 01/2012)|
|9.||Smale, Robert: 3 articles (04/2012 - 12/2011)|
|10.||Fu, Yao-Shi: 3 articles (04/2012 - 12/2011)|
04/01/2015 - "Background The folate receptor alpha is selectively over-expressed in a number of human cancers. "
01/15/2015 - "Targeting overexpressed folate receptor alpha (FRα) in cancer cells offers a therapeutic opportunity. "
01/01/2015 - "The folate receptor alpha (FR-α) has already been identified as a suitable target for cancer therapy and imaging. "
01/01/2015 - "Folate receptor alpha (FOLR1) has been identified as a potential prognostic and therapeutic target in a number of cancers. "
01/01/2014 - "Serum concentrations of the tumor-associated folate receptor 1 (FOLR1) protein may be a marker for early cancer detection, yet concentrations have also been detected in cancer-free women. "
04/01/2012 - "In patients with adenocarcinoma that underwent surgical resection, increased folate receptor alpha expression was associated with improved overall survival (Hazard Ratio 0.39, 95% CI 0.18-0.85). "
01/01/2015 - "Folate receptor alpha (FRA) is overexpressed in the majority of NSCLC, particularly in lung adenocarcinomas. "
05/01/2012 - "High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation."
04/01/2012 - "While 74% of adenocarcinomas were positive for folate receptor alpha expression, our results found that only 13% of squamous cell carcinomas were FRA positive (p<0.0001). "
04/01/2012 - "Folate receptor alpha expression was shown to have a high discriminatory capacity for lung adenocarcinomas versus squamous cell carcinomas. "
02/02/2010 - "This study investigates the response to pemetrexed in a panel of eight mesothelioma cell lines and the clinical outcome for patients treated with pemetrexed in relation to folate receptor alpha (FRalpha). "
05/01/2002 - "Despite some expression of folate receptor alpha in human mesothelioma cells, internalization of methotrexate is predominantly carrier mediated."
02/02/2010 - "The role of folate receptor alpha (FRalpha) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy."
05/01/2002 - "As a response to a published report documenting some expression of folate receptor alpha in human mesothelioma, studies were carried out examining the role of this receptor versus that of the reduced folate carrier in the internalization of folate analogs in this neoplasm. "
11/01/2008 - "The goal of this study was to evaluate the expression pattern and intracellular localization of alpha-folate receptor (alpha-FR) protein in human ovarian carcinoma compared with non-neoplastic ovarian tissue. "
10/01/2015 - "Folate Receptor Alpha Immunohistochemistry in Cytology Specimens of Metastatic Breast Carcinoma."
12/09/2014 - "Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. "
01/01/2001 - "The alpha-folate receptor (alpha FR) is overexpressed in 90% of nonmucinous ovarian carcinomas. "
01/05/1998 - "Folate receptor-alpha (FR-alpha) is generally over-expressed in non-mucinous human ovarian carcinomas. "
|5.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/01/2012 - "The goal of the present study was to evaluate the expression of folate receptor alpha in non-small cell lung cancer specimens to determine its frequency of expression and its potential for prognosis. "
04/01/2012 - "The distribution of folate receptor alpha expression in normal tissues as well as its expression and relationship to non-small cell lung cancer subtypes was assessed by immunohistochemistry using tissue microarrays and fine needle aspirates and an optimized manual staining method using the recently developed monoclonal antibody 26B3. "
01/01/2015 - "A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer."
04/01/2012 - "These data demonstrate the diagnostic relevance of folate receptor alpha expression in non-small cell lung cancer as determined by immunohistochemistry and suggest that determination of folate receptor alpha expression provides prognostic information in patients with lung adenocarcinoma."
01/01/2013 - "Significance of folate receptor alpha and thymidylate synthase protein expression in patients with non-small-cell lung cancer treated with pemetrexed."
|2.||Glucocorticoid Receptors (Glucocorticoid Receptor)
|3.||Folic Acid (Vitamin M)
|4.||Reduced Folate Carrier Protein
|6.||Amino Acid Transport Systems (Amino Acid Transporter)
|10.||Messenger RNA (mRNA)
|2.||Drug Therapy (Chemotherapy)