Folic Acid Transporters

Proteins involved in the transport of FOLIC ACID and folate derivatives across the CELLULAR MEMBRANE.

Also Known As:

Folate Transport Proteins; Folate Transporters; Folic Acid Transport Proteins; Acid Transporters, Folic; Proteins, Folate Transport; Transport Proteins, Folate; Transporters, Folate; Transporters, Folic Acid

Networked: 21 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Matherly, Larry H: 3 articles (03/2019 - 03/2007)
2.	Kaur, Jyotdeep: 3 articles (03/2013 - 03/2011)
3.	Wani, Nissar Ahmad: 3 articles (03/2013 - 03/2011)
4.	Hou, Zhanjun: 2 articles (04/2014 - 03/2007)
5.	Goldman, I David: 2 articles (04/2013 - 12/2010)
6.	Zhao, Rongbao: 2 articles (04/2013 - 12/2010)
7.	Khanduja, Krishan Lal: 2 articles (03/2013 - 03/2012)
8.	Chmurzynska, Agata: 1 article (04/2021)
9.	Kołodziejski, Paweł: 1 article (04/2021)
10.	Radziejewska, Anna: 1 article (04/2021)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2007 - "Many of the insights gained from laboratory models of RFC portend opportunities for modulating carrier expression in drug resistant tumors, and for designing a new generation of agents with improved transport by RFC or substantially enhanced transport by other folate transporters over RFC. " 04/01/2013 - "Folate transporters are routes of delivery of drugs for the treatment of cancer and inflammatory diseases. " 12/01/2010 - "Current synthetic efforts are focused on developing antifolates that are selectively delivered to cancer cells, but not to normal proliferating cells, exploiting the different properties of folate transporters. " 04/01/2014 - "The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer." 03/12/2019 - "This report provides a synopsis of the highlights presented in the following sessions: Barton Kamen Lecture; Targeting one-carbon metabolism in cytosol and mitochondria; Structure and biology of the one-carbon solute transporters; Physiology and pathophysiology of folate receptors and transporters; Folate receptors for targeting tumors and inflammatory diseases; Conventional and new anti-folate drugs for treating inflammatory diseases and cancer; Imaging; Ongoing clinical trials; and Chimeric Antigen Receptor cell therapies of cancer."
2.	Inflammation (Inflammations) 05/01/2015 - "Interestingly, VitD3 not only inhibited placental inflammation but also attenuated LPS-induced downregulation of placental folate transporters. " 04/01/2021 - "The aim of this study was to evaluate the effects of iron and folate deficiency and supplementation on blood morphology parameters, and to assess the role of iron and folate transporters in inflammation. "
3.	Pre-Eclampsia (Preeclampsia) 04/01/2012 - "The aim of the current study was to characterise the placental mRNA and protein expression of these folate transporters throughout gestation and also to see if expression is altered in pre-eclampsia. "
4.	Birth Weight (Birth Weights) 02/01/2016 - "Relationship between folate transporters expression in human placentas at term and birth weights." 02/01/2016 - "We aimed to study the relationship between placental mRNA and protein levels of folate transporters to birth weight. "
5.	Squamous Cell Carcinoma of Head and Neck 05/01/2019 - "The purpose of this study was to assess the expression of the 3 major folate transporters-folate receptors (FRs), reduced folate carrier (RFC), and proton-coupled folate transporter (PCFT)-in oral squamous cell carcinoma (OSCC). "

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Proteins (Proteins, Gene)
3.	Messenger RNA (mRNA)
4.	Reduced Folate Carrier Protein
5.	Proton-Coupled Folate Transporter
6.	Iron
7.	Carbon
8.	Chimeric Antigen Receptors
9.	Folate Receptor 1
10.	Member 1 Subfamily B ATP Binding Cassette Transporter

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)