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Contactin 2

A contactin subtype that plays a role in axon outgrowth, axon fasciculation, and neuronal migration.
Also Known As:
Axonin-1; TAG-1 Axonal Glycoprotein; TAX-1 Axonal Glycoprotein; Transient Axonal Glycoprotein 1; Axonal Glycoprotein, TAG-1; Axonal Glycoprotein, TAX-1; Axonin 1; TAG 1 Axonal Glycoprotein; TAX 1 Axonal Glycoprotein
Networked: 20 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Buckley, Camilla: 2 articles (12/2018 - 09/2010)
2. Irani, Sarosh R: 2 articles (12/2018 - 09/2010)
3. Lang, Bethan: 2 articles (12/2018 - 09/2010)
4. Pettingill, Philippa: 2 articles (12/2018 - 09/2010)
5. Vincent, Angela: 2 articles (12/2018 - 09/2010)
6. Waters, Patrick: 2 articles (12/2018 - 09/2010)
7. Meinl, Edgar: 2 articles (12/2011 - 05/2009)
8. Arimura, Kimiyoshi: 1 article (12/2018)
9. Birch, Ron: 1 article (12/2018)
10. Kiernan, Matthew C: 1 article (12/2018)

Related Diseases

1. Glioma (Gliomas)
05/10/2003 - "More recently, amplification and overexpression of the neighboring contactin 2 gene (CNTN2) was reported in individual malignant gliomas without MDM4 amplification (Rickman et al., Cancer Res 2001;61:2162-8). "
09/01/2010 - "By contrast, we found antibodies to three proteins that are complexed with (125)I-alpha-dendrotoxin-labelled potassium channels in brain extracts: (i) contactin-associated protein-2 that is localized at the juxtaparanodes in myelinated axons; (ii) leucine-rich, glioma inactivated 1 protein that is most strongly expressed in the hippocampus; and (iii) Tag-1/contactin-2 that associates with contactin-associated protein-2. "
12/01/2018 - "Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia."
06/01/2015 - "Extracellular antibodies are directed at cell-surface-expressed neuronal or glial proteins: glutamate receptors (N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazol-propionic acid), voltage-gated potassium channel complex (contactin-associated-protein 2 [CASPR2], contactin-2 and leucin-rich, glioma-inactivated 1 [LGI1]), and γ-aminobutyric acid (GABA) receptors (GABABR and GABAAR). "
12/01/2018 - "Although acquired autoimmune neuromyotonia (NMT) is associated with voltage-gated potassium channel (VGKC)-complex antibodies, to date there has been no systematic study of autoantibodies to the specific antigens leucine-rich glioma inactivated protein 1 (LGI1), contactin-associated protein 2 (CASPR2), and contactin 2 together with the full clinical syndrome, particularly pain and autonomic and central nervous system involvement. "
2. Fasciculation (Fasciculations)
3. Isaacs Syndrome (Neuromyotonia)
4. Pain (Aches)
5. Ganglion Cysts (Ganglion)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Antibodies
3. Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)
4. Leucine (L-Leucine)
5. Antigens
6. Immunoglobulins (Immunoglobulin)
7. Autoantibodies
8. Intravenous Immunoglobulins (IVIG)
9. Contactin 1
10. Contactins