Mucosal Administration

Delivery of a drug or other substance into the body through the epithelium lining of MUCOUS MEMBRANE involved with absorption and secretion.

Also Known As:

Administration, Mucosal; Transmucosal Administration; Transmucosal Administration Routes; Transmucosal Routing; Administration Route, Transmucosal; Administration Routes, Transmucosal; Administration, Transmucosal; Administrations, Mucosal; Administrations, Transmucosal; Mucosal Administrations; Route, Transmucosal Administration; Routes, Transmucosal Administration; Routing, Transmucosal; Routings, Transmucosal; Transmucosal Administration Route; Transmucosal Administrations; Transmucosal Routings

Networked: 91 relevant articles (17 outcomes, 14 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Drug Administration Routes: 28
    - Topical Administration: 1420
      - Mucosal Administration: 91
        Intranasal Administration: 1640
        Rectal Administration: 536

Experts

1.	Bonifacio, Ezio: 3 articles (04/2008 - 10/2004)
2.	Ebensen, Thomas: 2 articles (01/2017 - 12/2012)
3.	Guzmán, Carlos A: 2 articles (01/2017 - 12/2012)
4.	Chang, Jun: 2 articles (12/2013 - 01/2012)
5.	Song, Man Ki: 2 articles (12/2013 - 01/2012)
6.	Amedei, Amedeo: 2 articles (06/2009 - 11/2008)
7.	Berton, Giorgio: 2 articles (06/2009 - 11/2008)
8.	Codolo, Gaia: 2 articles (06/2009 - 11/2008)
9.	D'Elios, Mario Milco: 2 articles (06/2009 - 11/2008)
10.	Del Prete, Gianfranco: 2 articles (06/2009 - 11/2008)

Related Diseases

1.	Human Influenza (Influenza) 09/22/2015 - "Mucosal administration of raccoonpox virus expressing highly pathogenic avian H5N1 influenza neuraminidase is highly protective against H5N1 and seasonal influenza virus challenge." 12/01/2013 - "Combination of recombinant adenovirus (rAd) vector-based vaccine and mucosal administration is a promising regimen for safe and effective vaccination against influenza. " 01/01/2017 - "Mucosal Administration of Cycle-Di-Nucleotide-Adjuvanted Virosomes Efficiently Induces Protection against Influenza H5N1 in Mice." 09/30/2022 - "Enhanced Influenza Immunity by Nasal Mucosal Administration of the TPGS-Modified Liposomal Vaccine." 09/01/2015 - "The sM2HA2/CA-PMQ immunization was able to prevent disease symptoms, confering complete protection against lethal infection with divergent influenza subtypes (H5N1, H1N1, H5N2, H7N3, and H9N2) that lasted for at least 6 mo. Therefore, our data suggest that mucosal administration of sM2HA2 in combination with CA-PMQ could be a potent strategy for a broad cross-protective influenza vaccine, and CA-PMQ as a mucosal adjuvant could be used for effective mucosal vaccines."
2.	Infections 01/01/2023 - "Leveraging the mucosal administration safety of ChAdOx1, we targeted the site of M.tb infection to induce localized mucosal responses, while employing modified vaccinia virus (MVA) to boost systemic immune responses. " 11/01/2006 - "Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity." 01/01/2020 - "While intranasal delivery was proposed as the preferred administration route for therapeutic agents against viral pulmonary diseases, NP-based delivery systems offer numerous benefits to overcome challenges associated with mucosal administration, and ensure that these agents achieve a concentration that is many times higher than expected in the targeted sites of infection while limiting side effects on normal cells. " 06/01/2023 - "Mucosal administration of anti-bacterial antibodies provide long-term cross-protection against Pseudomonas aeruginosa respiratory infection." 11/01/2011 - "Whereas the great majority of the current vaccines are delivered through the parenteral route, mucosal administration has been increasingly considered for controlling infection and preventing disease. "
3.	Virus Diseases (Viral Diseases) 06/28/2022 - "In contrast, mucosal administration potentially offers the dual benefit of inducing potent mucosal and systemic immunity which would be more effective in offering protection against mucosal viral infection. " 01/01/2022 - "Our results unveil that the mucosal administration of a fully inactivated bacterial vaccine provides protection against viral infections by a mechanism associated with the induction of trained immunity." 01/01/2003 - "Adaptive (antigen induced) regulatory T cells are made by sub-optimal antigenic signals in the periphery, in the presence of immunosuppressive cytokines, often in special circumstances, such as chronic viral infections or after mucosal administration of antigen, and rely on cytokines such as IL-10 and TGF-beta for suppression. "
4.	Arthritis (Polyarthritis) 06/01/2002 - "Clinical arthritis in DBA/1 mice was monitored following mucosal administration of EtxB on 4 occasions. " 12/01/2011 - "A study was undertaken to determine whether mucosal administration of these bystander epitopes can be similarly effective in suppressing arthritis. " 12/01/2004 - "Mucosal administration of an autoantigen has been shown to be a powerful way of inducing tolerance in both animal and human arthritis clinical trials. " 09/24/2002 - "Mucosal administration of autoantigens decreases organ-specific inflammation and disease in several models of autoimmunity (diabetes, arthritis, and encephalomyelitis) and is also being tested in human clinical trials. " 04/26/2010 - "Mucosal administration of autoantigen HSP65 can induce anti-inflammatory immune response and decrease organ-specific inflammation and disease in several models of autoimmunity, such as arthritis and atherosclerosis. "
5.	Autoimmune Diseases (Autoimmune Disease) 01/01/2011 - "Based on above observations, several studies test the ability to prevent some autoimmune diseases by mucosal administration of respective antigens but with little to no success. " 11/01/2004 - "Among them, mucosal administration of autoantigen is an attractive mode of immunointervention still awaiting demonstration of clinical efficacy in human autoimmune diseases. " 01/01/2002 - "Several studies have demonstrated that mucosal administration of soluble antigens can prevent the onset or reduce the severity of certain autoimmune diseases or allergies. " 01/01/2013 - "Mucosal administration of an antigen eliciting bystander suppression at the site of inflammation results in effective antigen-specific immunotherapy for autoimmune diseases. " 12/01/2003 - "This novel method of mucosal tolerance induction by mucosal administration of recombinant lactobacilli expressing relevant autoantigens could find applications in autoimmune disease in general, such as multiple sclerosis, rheumatoid arthritis and uveitis."

Related Drugs and Biologics

1.	Vaccines
2.	Influenza Vaccines (Influenza Vaccine)
3.	Antigens
4.	Autoantigens
5.	Opioid Analgesics (Opioids)
6.	Epitopes
7.	Insulin (Novolin)
8.	Interleukin-12 (IL 12)
9.	Collagen
10.	Lectins

Related Therapies and Procedures

1.	Immunotherapy
2.	Microspheres (Microsphere)
3.	Critical Care (Surgical Intensive Care)