Lipoxygenases

07/22/2015 - "Recent studies have been explained the role of lipoxygenases (LOX) in the origin of cancer. "
10/01/2012 - "In the present study, we examined the kidney tissue from healthy individuals and cancer patients by immunohistochemical analysis for the presence of 3 lipoxygenases: 5-LOX, 12S-LOX and 15-LOX-1. "
01/01/2007 - "The involvement for lipoxygenases in tumor initiation and progression has been implicated in several studies but remains controversial. "
01/01/2023 - "Lipoxygenases are closely related to the development of various cancers. "
12/01/2022 - "The role of lipoxygenases was checked by inhibitors and gene silencing. Finally, the effect of DHA on ferroptosis-mediated tumor killing was verified in xenografts. "

08/01/2004 - "Lipoxygenases at the heart of atherosclerosis susceptibility."
06/15/2000 - "Lipoxygenases and atherosclerosis: protection versus pathogenesis."
06/01/1999 - "At last, direct evidence that lipoxygenases play a role in atherogenesis."
12/20/1996 - "Mammalian lipoxygenases are implicated in the biosynthesis of inflammatory mediators, in the pathogenesis of atherosclerosis and in the process of blood cell differentiation and maturation. "
10/01/1994 - "Cellular lipoxygenases have been implicated in foam cell formation during the early stages of atherogenesis. "

10/01/1987 - "The findings may indicate that activation of lipoxygenases may play a role during the initiation of the inflammatory reaction in arthritis."
01/01/2016 - "Because both inhibition of lipoxygenases and inhibition of matrix metalloproteinases are effective strategies in the treatment of rheumatoid arthritis, we investigated whether esculetin may be effective in adjuvant-induced arthritis in rats. "
05/01/1999 - "Lipoxygenases (LOX) are lipid-peroxidating enzymes that are implicated in the pathogenesis of a variety of inflammatory disorders such as arthritis, psoriasis, and asthma. "
01/01/2007 - "Here we give an overview of the interplay of cytokines and mechanical stress in the production of cyclooxygenases and prostaglandins; lipoxygenases and leukotrienes; and nitric oxide synthases and nitric oxide in arthritis, with particular focus on the interactions of these pathways in articular cartilage and meniscus."
01/01/2021 - "The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) and cytochrome P450 (CYP) enzymes to a spectrum of bioactive mediators that includes prostanoids, leukotrienes (LTs), epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid (diHETEs), eicosatetraenoic acids (ETEs), and lipoxins (LXs). "

01/01/2016 - "Because both inhibition of lipoxygenases and inhibition of matrix metalloproteinases are effective strategies in the treatment of rheumatoid arthritis, we investigated whether esculetin may be effective in adjuvant-induced arthritis in rats. "
01/01/2023 - "Mammalian lipoxygenases (LOXs) are involved in the biosynthesis of mediators of anaphylactic reactions and have been implicated in cell maturation, the pathogenesis of bronchial asthma, atherosclerosis, rheumatoid arthritis, cardiovascular diseases, Alzheimer's disease and osteoporosis. "

02/28/2005 - "Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes."