Adenosine A1 Receptor Agonists

Compounds that bind to and stimulate ADENOSINE A1 RECEPTORS.

Networked: 19 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Neurotransmitter Agents: 13181
      - Purinergic Agents: 10
        Purinergic Agonists: 39
        Purinergic P1 Receptor Agonists: 131
        Adenosine A1 Receptor Agonists: 19
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 13181
      - Purinergic Agents: 10
        Purinergic Agonists: 39
        Purinergic P1 Receptor Agonists: 131
        Adenosine A1 Receptor Agonists: 19

Experts

1.	Drew, Kelly L: 1 article (11/2019)
2.	Frare, Carla: 1 article (11/2019)
3.	Jenkins, Mackenzie E: 1 article (11/2019)
4.	McClure, Kelsey M: 1 article (11/2019)
5.	Chancellor, Michael B: 1 article (11/2014)
6.	Kitta, Takeya: 1 article (11/2014)
7.	Kuno, Sadako: 1 article (11/2014)
8.	Nonomura, Katsuya: 1 article (11/2014)
9.	Yoshimura, Naoki: 1 article (11/2014)
10.	de Groat, William C: 1 article (11/2014)

Related Diseases

1.	Overactive Urinary Bladder (Overactive Bladder) 11/01/2014 - "Thus adenosine A1 receptor agonists and A2A receptor antagonists might be effective for the treatment of overactive bladder and/or bladder hypersensitive disorders, in which C-fiber afferent function is enhanced."
2.	Seizures (Absence Seizure) 01/01/1994 - "Dose-response curves were constructed for the ability of theophylline to produce tonic seizures in animals pre-treated with vehicle or several adenosine A1 receptor agonists. " 03/26/1999 - "These data indicate that, contrary to other adenosine A1 receptor agonists whose chronic administration enhances postocclusive brain damage, ADAC may be a promising agent in treatment of both acute (e.g., cerebral ischemia) and chronic (seizures) disorders of the central nervous system in which adenosine A receptors appear to be involved." 10/05/1993 - "In contrast, the adenosine A1 and A2 receptor agonists both antagonized seizures induced by methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM--an inverse agonist at benzodiazepine receptors) and the adenosine A1 receptor agonists also protected against seizures induced by glutamate. "
3.	Brain Ischemia (Cerebral Ischemia) 04/29/1996 - "Our results indicate feasibility of further consideration of adenosine A1 receptor agonists as a clinically applicable acute treatment of brain ischemia. " 04/21/1994 - "The effect of chronic administration of selective adenosine A1 receptor agonists and antagonists on the outcome of cerebral ischemia is entirely unknown. " 03/26/1999 - "These data indicate that, contrary to other adenosine A1 receptor agonists whose chronic administration enhances postocclusive brain damage, ADAC may be a promising agent in treatment of both acute (e.g., cerebral ischemia) and chronic (seizures) disorders of the central nervous system in which adenosine A receptors appear to be involved."
4.	Ischemia 05/01/2009 - "Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine." 02/01/1996 - "Adenosine or adenosine A1 receptor agonists, muscarinic M2 receptor agonists, alpha 1-receptor agonists and bradykinin B2 receptor agonists as well as opening of the K+ATP-channel substitute for ischemia in the induction of protection. "
5.	Hyperalgesia 09/01/2010 - "Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats." 05/15/1998 - "administration of GABA(B) or adenosine A1 receptor agonists (baclofen, R(-)-N6-(2-phenylisopropyl)adenosine (R-PIA)) suppressed allodynia in a dose-dependent fashion. "

Related Drugs and Biologics

1.	Adenosine (Adenocard)
2.	Bradykinin B2 Receptor
3.	Muscarinic M2 Receptor
4.	Glutamic Acid (Glutamate)
5.	Theophylline (Theon)
6.	GABA-A Receptors (GABA(A) Receptor)
7.	Naloxone (Narcan)
8.	Morphine (MS Contin)
9.	gamma-Aminobutyric Acid (GABA)
10.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Therapeutics
2.	Induced Hypothermia