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Sterol 14-Demethylase

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Also Known As:
CYP51 Cytochrome P-450; Cytochrome P-450 CYP51; Eburicol 14 alpha-Demethylase; Eburicol 14alpha-Demethylase; Lanosterol 14 alpha-Demethylase; Obtusifoliol 14alpha-Demethylase; Sterol 14-alpha-Demethylase; 14 alpha-Demethylase, Eburicol; 14 alpha-Demethylase, Lanosterol; 14-Demethylase, Sterol; 14-Demethylases, Sterol; 14-alpha-Demethylase, Sterol; 14alpha-Demethylase, Eburicol; 14alpha-Demethylase, Obtusifoliol; CYP51 Cytochrome P 450; CYP51, Cytochrome P-450; Cytochrome P 450 CYP51; Cytochrome P-450, CYP51; Eburicol 14 alpha Demethylase; Eburicol 14alpha Demethylase; Lanosterol 14 alpha Demethylase; Obtusifoliol 14alpha Demethylase; P-450 CYP51, Cytochrome; P-450, CYP51 Cytochrome; Sterol 14 Demethylase; Sterol 14 Demethylases; Sterol 14 alpha Demethylase; Sterol 14-Demethylases
Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Buckner, Frederick S: 2 articles (12/2012 - 01/2008)
2. Ramasamy, Gnanam: 1 article (05/2022)
3. Ravikumar, Caroline: 1 article (05/2022)
4. Sekar, Vinusri: 1 article (05/2022)
5. Debnath, Anjan: 1 article (01/2020)
6. McKerrow, James H: 1 article (01/2020)
7. Podust, Larissa M: 1 article (01/2020)
8. Shing, Brian: 1 article (01/2020)
9. Singh, Seema: 1 article (01/2020)
10. Urbina, Julio A: 1 article (12/2012)

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2. Sterols