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Sterol 14-Demethylase

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Also Known As:
CYP51 Cytochrome P-450; Cytochrome P-450 CYP51; Eburicol 14 alpha-Demethylase; Eburicol 14alpha-Demethylase; Lanosterol 14 alpha-Demethylase; Obtusifoliol 14alpha-Demethylase; Sterol 14-alpha-Demethylase; 14 alpha-Demethylase, Eburicol; 14 alpha-Demethylase, Lanosterol; 14-Demethylase, Sterol; 14-Demethylases, Sterol; 14-alpha-Demethylase, Sterol; 14alpha-Demethylase, Eburicol; 14alpha-Demethylase, Obtusifoliol; CYP51 Cytochrome P 450; CYP51, Cytochrome P-450; Cytochrome P 450 CYP51; Cytochrome P-450, CYP51; Eburicol 14 alpha Demethylase; Eburicol 14alpha Demethylase; Lanosterol 14 alpha Demethylase; Obtusifoliol 14alpha Demethylase; P-450 CYP51, Cytochrome; P-450, CYP51 Cytochrome; Sterol 14 Demethylase; Sterol 14 Demethylases; Sterol 14 alpha Demethylase; Sterol 14-Demethylases
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Bio-Agent Context: Research Results

Experts

1. Buckner, Frederick S: 1 article (01/2008)

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1. Infection