|3.||Breast Neoplasms (Breast Cancer)
|5.||Cardiovascular Diseases (Cardiovascular Disease)
|1.||Cauley, Jane A: 24 articles (12/2015 - 01/2004)|
|2.||Ensrud, Kristine E: 21 articles (03/2015 - 01/2004)|
|3.||Kanis, J A: 17 articles (07/2014 - 04/2001)|
|4.||Barrett-Connor, Elizabeth: 15 articles (10/2015 - 09/2003)|
|5.||Uitterlinden, André G: 15 articles (05/2015 - 05/2004)|
|6.||Cummings, Steven R: 13 articles (10/2015 - 03/2002)|
|7.||van Schoor, Natasja M: 12 articles (05/2015 - 04/2006)|
|8.||Lips, Paul: 12 articles (05/2015 - 05/2004)|
|9.||Ohlsson, Claes: 12 articles (12/2014 - 08/2010)|
|10.||van Meurs, Joyce B J: 11 articles (10/2015 - 05/2004)|
|1.||Vitamin DFDA LinkGeneric
03/01/2012 - "Adequate levels of vitamin D correlate with greater bone mineral density, lower rates of osteoporotic fractures, and improved neuromuscular function. "
12/01/2010 - "The efficacy of vitamin D on osteoporotic fractures is thought to be through direct effects on bone and indirect effects on muscles that help to prevent falls. "
04/15/2009 - "Epidemiological studies revealed a dose-dependent association between serum 25-OHD levels and pulmonary function so that adequate vitamin D supplementation may extend beyond its protection against osteoporotic fractures. "
01/01/2015 - "The objective of the study was to evaluate the relationship between protein and vitamin D intake with the occurrence of falls in older women in the Study of Osteoporotic Fracture, a prospective cohort of more than 4000 postmenopausal women participating from January 1997 to September 1998. "
12/01/2014 - "This study of elderly Swedish women investigated the association between chronic vitamin D insufficiency and osteoporotic fractures occurring between ages 80-90. "
03/01/1990 - "Although the efficacy of exercise and calcium supplementation to prevent osteoporotic fractures has not been well established, these measures are commonly advocated by both generalists and subspecialists. "
05/01/2002 - "Furthermore, our results suggest that adequate calcium intake may help to enhance bone mass, thus decreasing the risk of osteoporotic fracture later in life."
02/15/2011 - "In three of the five trials, subgroup analysis of the most treatment-adherent participants indicated significant reductions in osteoporotic fracture risk with calcium supplement use. "
08/01/2008 - "Observational data from the Study of Osteoporotic Fractures show a similar increase in risk of hip fracture associated with calcium use. "
01/01/2008 - "The effect and influence of calcium intake in the prevention of osteoporotic fracture vary from different studies. "
|3.||Alendronate (Alendronate Sodium)FDA LinkGeneric
06/01/2005 - "These data show that alendronate is effective in reducing the risk of symptomatic osteoporotic fractures across a spectrum of ages. "
01/01/2008 - "To assess the efficacy of alendronate in the primary and secondary prevention of osteoporotic fractures in postmenopausal women. "
01/01/2013 - "Characteristics of patients who suffer major osteoporotic fractures despite adhering to alendronate treatment: a National Prescription registry study."
01/01/2011 - "Two thousand seven hundred seventy-seven women aged 55 to 80 randomized to the placebo arms of the Fracture Intervention Trial, a randomized controlled trial of the effect of alendronate on risk for osteoporotic fractures. "
10/01/2008 - "The Fracture Intervention Trial (FIT) evaluated the effectiveness of alendronate at 5 mg/day (first 2 years) followed by 10 mg/day (third year) vs placebo over 3-4 years in preventing osteoporotic fractures. "
12/01/2012 - "Despite the proven benefit of bisphosphonates at providing protection against osteoporotic fractures, caution should be used before continuing therapy for longer than 5 years."
01/01/2008 - "Oral bisphosphonates are effective for reducing the risk of osteoporotic fractures and are an important treatment option for patients at risk for this condition. "
09/01/2014 - "Effectiveness of oral bisphosphonates for primary prevention of osteoporotic fractures: evidence from the AIFA-BEST observational study."
12/01/2012 - "Bisphosphonates reduce the rate of osteoporotic fractures in clinical trials and community practice. "
07/01/2010 - "Compared with the reduction in classical osteoporotic fractures, the risk of harm caused by bisphosphonates is low, according to information presently available from clinical trials and from health databases. "
|5.||strontium ranelate (protelos)IBA
06/01/2013 - "Recently, open-label extensions of the SOTI and TROPOS trials up to 8 and, recently, 10 years have confirmed the sustained efficacy of strontium ranelate in increasing BMD, the long-term safety profile and the high compliance to treatment, independently from baseline BMD or other risk factors for osteoporotic fractures. "
02/01/2007 - "Strontium ranelate was shown to be clinically effective in the prevention of osteoporotic fractures. "
10/01/2009 - "Continuous broad protection against osteoporotic fractures with strontium ranelate."
02/01/2003 - "In a phase II study, the effect of strontium ranelate in postmenopausal women with vertebral osteoporotic fractures was assessed during a double-blind, placebo-controlled trial. "
08/01/2011 - "Treatment with strontium ranelate was associated with a significant 31% decrease in all clinical osteoporotic fractures (vertebral fractures included). "
|6.||Raloxifene (Evista)FDA Link
05/01/2004 - "These data suggest that the efficacy of raloxifene in reducing vertebral fractures is largely independent of the presence of clinical risk factors for osteoporotic fractures."
05/01/2004 - "The efficacy of raloxifene in reducing vertebral fractures is largely independent of the presence of clinical risk factors for osteoporotic fractures. "
06/01/2008 - "In this review, we provide an overview of the evidence accumulated to data on the effect of raloxifene in the prophylaxis of osteoporotic fractures. "
06/01/2008 - "Role of raloxifene in the prevention of osteoporotic fractures]."
01/01/2008 - "Raloxifene patients were younger, had better overall health status and appeared to be less likely to have risk factors for new osteoporotic fractures than bisphosphonate patients. "
03/01/2013 - "Twice-yearly denosumab treatment is associated with markedly improved bone mineral density (BMD) and cortical and trabecular bone strength, and significantly reduced osteoporotic fracture. "
10/01/2013 - "So, promising results in terms of therapeutic efficacy and reliability make desirable the wide clinical use of denosumab for the treatment of osteoporotic fractures in the near future."
05/01/2011 - "Denosumab has been shown in a large randomised trial to reduce the frequency of osteoporotic fractures when given subcutaneously at 6-monthly intervals. "
02/01/2015 - "Denosumab is a novel antiresorptive drug that has been approved for use as a first-line drug for primary and secondary prevention of osteoporotic fractures. "
05/01/2014 - "Denosumab is the only agent that has been shown to prevent osteoporotic fractures in men receiving androgen deprivation therapy and at elevated risk for fracture. "
|8.||Estrogens (Estrogen)FDA Link
01/01/2011 - "Estrogen therapy (in hysterectomized women) and estrogen/progestogen therapy (in nonhysterectomized women) are the most effective treatments available for the relief of vasomotor and urogenital symptoms in postmenopausal women and provide significant protection against osteoporotic fractures. "
08/21/2002 - "Protection against osteoporotic fractures is supported by a meta-analysis of 22 estrogen trials, cohort studies, results of the WHI, and trials with bone density outcomes. "
05/01/2012 - "Baseline characteristics differed significantly among the 6,616 women within the Study of Osteoporotic Fractures who underwent either surgical (1,157) or natural (5,459) menopause, including mean age at menopause (44.3 ± 7.4 vs 48.9 ± 4.9 y, P < 0.001) and current use of oral estrogen (30.2% vs 6.5%, P < 0.001). "
01/26/2004 - "To determine whether statin use is associated with a reduced risk for fracture, we analyzed statin use and fracture rates in 4 large prospective studies (the Study of Osteoporotic Fractures, the Fracture Intervention Trial, the Heart and Estrogen/Progestin Replacement Study, and the Rotterdam Study). "
02/13/1995 - "To determine the effect of postmenopausal estrogen use on muscle strength, neuromuscular function, and the risk of falling, we examined 9704 participants aged 65 years or more enrolled in the Study of Osteoporotic Fractures. "
|9.||Calcitonin (Calcitonin, Eel)FDA LinkGeneric
05/01/2002 - "The efficacy of nasal calcitonin treatment to reduce vertebral fracture rate has been best examined in the PROOF (Prevent Recurrence of Osteoporotic Fractures) study. "
09/01/2003 - "The Prevent Recurrence Of Osteoporotic Fractures (PROOF) study has shown a significant decrease in the risk of vertebral fracture in patients treated with calcitonin 200 IU. "
05/01/2002 - "Currently, there is still no prospective, placebo-controlled study with a sufficient number of patients that demonstrates that long-term parenteral calcitonin administration reduces the risk of osteoporotic fractures. "
11/01/2002 - "The analgesic role of calcitonin following osteoporotic fracture."
09/01/1993 - "Calcitonin has a specific role in prevention and treatment of osteoporotic fractures. "
08/01/2004 - "Is dietary counselling effective in increasing dietary calcium, protein and energy intake in patients with osteoporotic fractures? "
07/01/1991 - "Given the differences in diet-assessment methods, studies of dietary calcium and osteoporotic fracture have had surprisingly similar results."
04/24/2006 - "Increased dietary calcium intake has been proposed as a population-based public health intervention to prevent osteoporotic fractures. "
01/01/1997 - "The pathogenesis of age-related osteoporotic fracture: effects of dietary calcium deprivation."
08/01/2005 - "One of the main focuses of lifestyle modification for the prevention of osteoporosis and osteoporotic fractures in Japan is improvement in dietary calcium intake. "
06/01/2004 - "Vertebroplasty is most commonly used to treat painful osteoporotic fracture resistant to conservative therapy, but may be helpful in other conditions such as malignant collapse. "
01/01/2015 - "Percutaneous vertebroplasty (PVP) has been demonstrated to be effective in the treatment of osteoporotic fracture. "
12/01/2010 - "The aim of this study was to evaluate feasibility and efficacy of navigated percutaneous screw fixation combined with multisegmental vertebroplasty for the treatment of osteoporotic fractures not suitable for monosegmental cement augmentation in patients with severe osteoporotic changes of the vertebral column and/or progressive kyphotic deformation. "
01/01/2015 - "This is a blinded trial of Vertebroplasty for Acute Painful Osteoporotic fractURes - the VAPOUR trial. "
01/01/2015 - "Vertebroplasty for acute painful osteoporotic fractures (VAPOUR): study protocol for a randomized controlled trial."
|2.||Hormone Replacement Therapy (Therapy, Hormone Replacement)
01/01/2009 - "Among the several therapeutical interventions, hormone replacement therapy (HRT) was traditionally seen as the gold standard for preventing osteoporotic fractures in postmenopausal women, as well as for the management of menopausal symptoms. "
03/01/2004 - "The Women's Health Initiative Study (WHI) reported that hormone replacement therapy (HRT) prevented osteoporotic fractures. "
04/01/2001 - "The aim of this study was to model the effect of short (3-year) treatments with hormone replacement therapy (HRT) at the time of menopause on the risk of osteoporotic fracture, and to assess the impact of strategies to target high-risk individuals. "
06/01/2011 - "A review of the role of hormone replacement therapy in younger women with significant risk of osteoporotic fractures may be timely in these circumstances."
08/31/2006 - "Hormone Replacement Therapy is not applied in prevention of osteoporotic fracture, however, it is still in use in treatment of disorders of menopause. "
|3.||Estrogen Replacement Therapy
02/01/2011 - "Estrogen replacement is traditionally seen as the gold standard for preventing osteoporotic fractures in postmenopausal women as well as for the management of menopausal symptoms. "
04/01/2003 - "(9) The WHI trial confirmed the beneficial impact of estrogen-progestin combination therapy on the risk of osteoporotic fracture. "
01/01/2003 - "Observational studies and recent randomized trials have shown that postmenopausal hormone replacement therapy (HRT) may reduce the risk of osteoporotic fractures by about 30 to 40%. "
11/01/2001 - "Effects of current and discontinued estrogen replacement therapy on hip structural geometry: the study of osteoporotic fractures."
07/15/2001 - "Back problems among postmenopausal women taking estrogen replacement therapy: the study of osteoporotic fractures."
12/01/2015 - "Balloon kyphoplasty of T8 in an osteoporotic fracture."
09/01/2015 - "This case report indicates that kyphoplasty can be an alternative method for selective pediatric intractable painful vertebral glucocorticoid-induced osteoporotic fractures, but it should be performed after careful consideration in pediatric group. "
06/01/2015 - "[Effects of different treatments on patients with osteoporotic fracture after percutaneous kyphoplasty]."
08/01/2014 - "Kyphoplasty is a good procedure for treating painful osteoporotic fractures from the lumbar to the thoracic spine. "
06/01/2014 - "Incidence and risk factors for early adjacent vertebral fractures after balloon kyphoplasty for osteoporotic fractures: analysis of the SWISSspine registry."
|5.||Drug Therapy (Chemotherapy)
03/01/2011 - "Pharmacotherapy is effective in decreasing the incidence of osteoporotic fracture, morbidity, and mortality. "
01/01/2005 - "This study suggests that BMD thresholds for drug therapy to prevent osteoporotic fracture should be only modestly adjusted in those with prior wrist fracture compared with those without prior wrist fracture. "
12/01/2014 - "Post-fracture pharmacotherapy for women with osteoporotic fracture: analysis of a managed care population in the USA."
12/01/2012 - "Osteoporotic fractures carry a substantial burden of morbidity and mortality, but pharmacotherapy can prevent such fractures in high-risk individuals. "
01/01/2005 - "Prior wrist fracture has been identified as a risk factor for incident hip and vertebral fractures and proposed as a criterion for determining who should be offered drug therapy to prevent osteoporotic fracture, even if their hip BMD T score is > -2.5. "