Serotonin 5-HT3 Receptor Agonists

Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT3 RECEPTORS.

Also Known As:

5-HT3 Agonist; 5-HT3 Agonists; 5 HT3 Agonist; 5 HT3 Agonists; Agonist, 5-HT3; Agonists, 5-HT3; Serotonin 5 HT3 Receptor Agonists

Networked: 15 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Neurotransmitter Agents: 13181
      - Serotonin Agents: 404
        Serotonin Receptor Agonists: 392
        Serotonin 5-HT3 Receptor Agonists: 15
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 13181
      - Serotonin Agents: 404
        Serotonin Receptor Agonists: 392
        Serotonin 5-HT3 Receptor Agonists: 15

Experts

1.	Crossley, Dane A: 1 article (01/2021)
2.	Eme, John: 1 article (01/2021)
3.	Rhen, Turk: 1 article (01/2021)
4.	Tate, Kevin B: 1 article (01/2021)
5.	Iha, Higor A: 1 article (06/2017)
6.	Kunisawa, Naofumi: 1 article (06/2017)
7.	Matsubara, Nami: 1 article (06/2017)
8.	Nomura, Yuji: 1 article (06/2017)
9.	Ohno, Yukihiro: 1 article (06/2017)
10.	Onishi, Misaki: 1 article (06/2017)

Related Diseases

1.	Seizures (Absence Seizure) 11/01/2016 - "The data indicate that systemic administration of SR 57227, a 5-HT3 agonist, was effective in blocking S-IRA in doses that did not block seizures, and the S-IRA blocking effect of the SSRI, fluoxetine, was abolished by coadministration of a 5-HT3 antagonist, ondansetron. "
2.	Vomiting 04/14/1994 - "Plasticity of emesis to a 5-HT3 agonist: effect of order of visceral nerve cuts." 11/15/2003 - "Although 5-HT3 antagonists have been used to treat chemotherapy-induced emesis and diarrhoea-predominant irritable bowel syndrome, the effects of 5-HT3 agonists in humans are unknown. " 01/17/1991 - "Further, the putative 5-HT3 agonists, 2-methyserotonin and phenylbiguanide, at 10 mg/kg p.o., produced emesis that was blocked by zacopride (0.1 mg/kg i.p.) or ICS 205-930 (1 mg/kg i.p.). " 11/01/1995 - "In the pigeon, LY228729 totally abolished vomiting induced by fully emetic doses of cisplatin (10 mg/kg), ipecac (3 ml/kg), emetine (10 mg/kg), and a 5-HT3 agonist, m-(chlorophenyl)-biguanide (1.25 mg/kg). "
3.	Bradycardia 01/01/2021 - "Injections of the 5-HT3 agonist phenylbiguanide (PBG) caused a pronounced bradycardia that decreased in intensity at 90% of incubation in embryos from the normoxic group while the heart rate response was unchanged in the hypoxic group. " 11/10/1998 - "The bradycardia and hypotension that characterizes the Bezold-Jarisch reflex, induced by the 5-HT3, agonist phenyldiguanide (1.5-24.0 microg/kg, i.v.), were significantly decreased in MHR compared to CR. " 03/01/1997 - "Microinjections of 5-HT (2.5-5 nmol) or the 5-HT3 agonist 1-(m-chlorophenyl)-biguanide (CPBG, 300-1,200 pmol) into the commissural NTS blocked in a dose-dependent manner the atropine-sensitive chemoreflex bradycardia elicited by KCN. "
4.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 11/15/2003 - "Although 5-HT3 antagonists have been used to treat chemotherapy-induced emesis and diarrhoea-predominant irritable bowel syndrome, the effects of 5-HT3 agonists in humans are unknown. "
5.	Tremor (Tremors) 06/01/2017 - "The 5-HT3 agonist SR-57227 did not affect nicotine-induced tremor. "

Related Drugs and Biologics

1.	Serotonin 5-HT3 Receptor Antagonists
2.	Ondansetron (Zofran)
3.	Fluoxetine (Prozac)
4.	Serotonin (5 Hydroxytryptamine)
5.	phenyl biguanide
6.	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
7.	2-methyl-5-HT
8.	Serotonin 5-HT2 Receptor Agonists
9.	Serotonin 5-HT1 Receptor Agonists
10.	5-HT1A Serotonin Receptor

Related Therapies and Procedures

1.	Injections
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)