Neuroprostanes

Prostaglandin-like compounds produced by free radical-induced peroxidation of DOCOSAHEXAENOIC ACIDS, which are highly enriched in the brain. Formation is analogous to ISOPROSTANES formation from ARACHIDONIC ACID.

Networked: 21 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Durand, Thierry: 5 articles (01/2022 - 11/2011)
2.	Galano, Jean-Marie: 5 articles (01/2022 - 11/2011)
3.	Roberts, L Jackson: 4 articles (01/2012 - 09/2002)
4.	Oger, Camille: 3 articles (01/2022 - 01/2019)
5.	Leoncini, Silvia: 3 articles (01/2019 - 03/2009)
6.	Signorini, Cinzia: 3 articles (01/2019 - 03/2009)
7.	Mori, Trevor A: 3 articles (06/2014 - 11/2011)
8.	Vigor, Claire: 2 articles (01/2022 - 08/2021)
9.	De Felice, Claudio: 2 articles (01/2019 - 07/2011)
10.	Hayek, Joussef: 2 articles (01/2019 - 07/2011)

Related Diseases

1.	Hypoxia (Hypoxemia) 06/01/2014 - "Levels of F₂-isoprostanes and F₄-neuroprostanes were low and variable in zebrafish brains such that statistically significant changes due to hypoxia or chemical mimicry of hypoxia could not be observed. " 09/01/2012 - "Hypoxia and reoxygenation significantly increased the levels of isoprostanes, isofurans, neuroprostanes, and neurofurans in the cerebral cortex. " 10/01/2023 - "At 1 month, positive associations were found between several hypoxemia parameters with quantiles of isoprostanes, dihomo-isoprostanes and dihomo-isofurans and a negative correlation with isoprostanes, isofurans, neuroprostanes, and meta-tyrosine. "
2.	Alzheimer Disease (Alzheimer's Disease) 01/01/2001 - "Quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease." 01/01/2001 - "Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease." 09/24/2002 - "The formation of neuroprostanes, isoprostane-like compounds formed from oxidation of docosahexaenoic acid, which is uniquely enriched in the brain, is increased in Alzheimer's disease. "
3.	Cognitive Dysfunction 01/01/2010 - "F2-isoprostanes (F2-IsoPs) levels and neuroprostanes were also significantly increased in mild cognitive impairment (MCI) patients and in late-stage AD. " 03/14/2022 - "Lipid peroxidation compounds (prostaglandins, isoprostanes, isofurans, neuroprostanes, neurofurans, dihomo-isoprostanes and dihomo-isofurans) were analysed by liquid chromatography and mass spectrometry in plasma samples from participants classified into a healthy group (n = 80), a mild cognitive impairment due to AD group (n = 106), a mild dementia due to AD group (n = 70), an advanced dementia due to AD group (n = 11) and a group of other non-AD dementias (n = 20). "
4.	Obesity 01/01/2022 - "Thus we investigated whether pWAT produced oxygenated lipids, namely isoprostanes and neuroprostanes and whether they can influence β-cell function in obesity. " 08/12/2021 - "Decreased Fatty Acid Transporter FABP1 and Increased Isoprostanes and Neuroprostanes in the Human Term Placenta: Implications for Inflammation and Birth Weight in Maternal Pre-Gestational Obesity."
5.	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 03/01/2009 - "Free iron, total F-isoprostanes and total F-neuroprostanes in a model of neonatal hypoxic-ischemic encephalopathy: neuroprotective effect of melatonin."

Related Drugs and Biologics

1.	Isoprostanes
2.	F2-Isoprostanes (F2 Isoprostanes)
3.	Biomarkers (Surrogate Marker)
4.	Docosahexaenoic Acids
5.	Acids
6.	Neuroprotective Agents
7.	Uric Acid (Urate)
8.	Superoxides (Superoxide)
9.	Prostaglandins
10.	Phosphates (Orthophosphate)