Composite Lymphoma

Two or more distinct types of malignant lymphoid tumors occurring within a single organ or tissue at the same time. It may contain different types of non-Hodgkin lymphoma cells or both Hodgkin and non-Hodgkin lymphoma cells.

Also Known As:

Networked: 29 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
2.	Lymphoma (Lymphomas)
3.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
4.	Neoplasms (Cancer)
5.	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)

Experts

1.	Burdaspal, Ana: 1 article (11/2020)
2.	Castro, Yolanda: 1 article (11/2020)
3.	Díez-Martín, José-Luis: 1 article (11/2020)
4.	González-Gascón Y Marín, Isabel: 1 article (11/2020)
5.	Hernández-Rivas, José-Ángel: 1 article (11/2020)
6.	Infante, María Stefania: 1 article (11/2020)
7.	Kwon, Mi: 1 article (11/2020)
8.	Martínez-Laperche, Carolina: 1 article (11/2020)
9.	Menarguez, Javier: 1 article (11/2020)
10.	Chen, Yudi: 1 article (09/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Composite Lymphoma:

1.	Methotrexate (Mexate)FDA LinkGeneric 02/01/2010 - "We report the case of a 67 year-old woman with a long history of rheumatoid arthritis, on methotrexate treatment, who developed multiple skin lesions exhibiting a malignant infiltrate displaying both B- and T-cell phenotypes and dual clonal gene rearrangement by polymerase chain reaction, consistent with a cutaneous composite lymphoma. " 05/01/2006 - "Methotrexate-associated lymphoproliferative disorder mimicking composite lymphoma." 01/01/2020 - "Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer."
2.	Proteins (Proteins, Gene)FDA Link 02/01/2016 - "The increased and frequent morphologic presence of HRS-L cells in association with this composite lymphoma raises a possible link between their occurrence and DLBCLs in PTCLs; furthermore, the frequent detection of MYC protein expression and EBV infection in these cases suggests a possible role of these pathways in B-cell lymphomagenesis. " 04/01/2004 - "Epstein-Barr virus-associated composite lymphoma composed of peripheral T-cell lymphoma and an anaplastic variant of a diffuse large B-cell type of non-Hodgkin's lymphoma and strongly expressing p53 protein."
3.	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 01/01/2020 - "Immunoglobulin heavy chain and light chain rearrangements analysis by PCR proved that both components of the orbital tumor were recurrences of the same nodal composite lymphoma diagnosed two years earlier. " 07/01/2001 - "Six gastric lymphomas, consisting of two MZBL, MALT type, two DLBCL, and two "composite" lymphomas were subjected to laser capture microdissection and subsequent PCR-based amplification of the immunoglobulin heavy chain gene. "
4.	Rituximab (Mabthera)FDA Link 03/01/2007 - "Composite lymphoma of the orbit treated with rituximab." 11/16/2023 - "To our knowledge, this is the first case of composite lymphoma presenting with distributive shock and treated with BV and rituximab, with successful resolution of shock."
5.	Proto-Oncogene Proteins c-relIBA 01/01/2017 - "c-REL amplification was limited to 6/22 large cell MZBL including the large cell component of 2/9 composite small cell/large cell lymphomas, and c-Rel protein expression was found in the large cell compartment of composite lymphomas. "
6.	Ki-1 AntigenIBA 01/01/1992 - "It is, therefore, unusual to find Ki-1 antigen component in a composite lymphoma of B-cell origin in an adult. "
7.	RNA (Ribonucleic Acid)IBA 01/01/2018 - "RNA in situ hybridization allowed for recognition of biclonal/composite lymphomas not identified by flow cytometry and highlighted unexpected findings, such as coexpression of kappa and lambda RNA in 2 cases and the presence of lambda light chain RNA in a T lymphoblastic lymphoma. "
8.	LigandsIBA 02/01/2020 - "Diagnostic utility of programmed cell death ligand 1 (clone SP142) in mediastinal composite lymphoma: A report of two cases."
9.	Immunoglobulin Variable RegionIBA 05/01/2001 - "We analyzed two composite lymphomas (a combination of classical HD with follicular lymphoma [FL] and a combination of classical HD with B-cell chronic lymphocytic leukemia [B-CLL]) by micromanipulation of single cells from tissue sections and amplification of immunoglobulin V region genes for the clonal relationship of the tumor cells. "
10.	Hematoxylin (Haematoxylon)IBA 10/07/2013 - "Surgery was performed and the disease was diagnosed pathologically as composite lymphoma of DLBCL and cHL using hematoxylin-eosin and immunohistochemical staining. "

Therapies and Procedures

1.	Transplantation 09/01/1981 - "Four of the seven patients (two with diffuse poorly differentiated lymphocytic lymphoma, one with composite lymphoma, and one with diffuse moderately well differentiated lymphocytic lymphoma) remain in complete unmaintained remission 12-126 mo from transplantation. "
2.	Therapeutics 01/01/2018 - "Treatments for AITL and DLBCL composite lymphoma include chemotherapy, targeted therapy, immunomodulatory therapy and hematopoietic stem cell transplantation, but no standard treatment for this aggressive disease has yet been defined. " 09/01/2020 - "Cutaneous composite lymphoma of mycosis fungoides and Hodgkin lymphoma: Response to sequential therapy." 06/01/2014 - "Therapy-related acute myeloblastic leukemia after splenectomy in a patient with composite lymphoma developing after treatment of chronic lymphocytic leukemia."
3.	Splenectomy 02/01/2000 - "Unexpected consequence of splenectomy in composite lymphoma. " 10/01/2014 - "Splenectomy and excisional biopsy of abdominal lymph node were performed and disease was diagnosed as composite lymphoma, consisting of diffuse large B-cell lymphoma and nodular sclerosing Hodgkin lymphoma. " 06/01/2014 - "Therapy-related acute myeloblastic leukemia after splenectomy in a patient with composite lymphoma developing after treatment of chronic lymphocytic leukemia."
4.	Drug Therapy (Chemotherapy) 02/01/2005 - "Sequential application of chemotherapy and monoclonal CD 20 antibody: successful treatment of advanced composite-lymphoma." 02/01/2005 - "In conclusion, in the very rare case of composite lymphoma a combination of chemotherapy and subsequent immunotherapy might be considered as a promising therapeutic option." 01/01/2018 - "Treatments for AITL and DLBCL composite lymphoma include chemotherapy, targeted therapy, immunomodulatory therapy and hematopoietic stem cell transplantation, but no standard treatment for this aggressive disease has yet been defined. " 05/01/2013 - "Composite lymphoma after chemotherapy with regressed diffuse large B-cell lymphoma and transformed cytotoxic T-cell lymphoma."
5.	Immunomodulation 01/01/2018 - "Treatments for AITL and DLBCL composite lymphoma include chemotherapy, targeted therapy, immunomodulatory therapy and hematopoietic stem cell transplantation, but no standard treatment for this aggressive disease has yet been defined. "