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Decorin

A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.
Also Known As:
Bone Proteoglycan II; DSPG-II; II, Bone Proteoglycan; Proteoglycan II, Bone
Networked: 629 relevant articles (24 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Iozzo, Renato V: 55 articles (12/2015 - 03/2002)
2. Schaefer, Liliana: 16 articles (10/2015 - 03/2002)
3. Owens, Rick T: 16 articles (04/2014 - 02/2005)
4. Neill, Thomas: 12 articles (12/2015 - 12/2010)
5. Seidler, Daniela G: 10 articles (05/2013 - 08/2004)
6. Wight, Thomas N: 7 articles (04/2015 - 10/2002)
7. Buraschi, Simone: 7 articles (04/2014 - 12/2010)
8. Tredget, Edward E: 6 articles (08/2015 - 05/2011)
9. Iozzo, R V: 6 articles (03/2015 - 10/2000)
10. Postma, Dirkje S: 6 articles (10/2013 - 03/2005)

Related Diseases

1. Fibrosis (Cirrhosis)
2. Neoplasms (Cancer)
3. Cicatrix (Scar)
4. Neoplasm Metastasis (Metastasis)
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Collagen
2. Transforming Growth Factor beta (TGF-beta)
3. Messenger RNA (mRNA)
4. Phosphotransferases (Kinase)
5. Liposomes (Liposome)
6. Proteoglycans (Proteoglycan)
7. Biglycan
8. Transforming Growth Factor beta1 (TGF beta 1)
9. Procollagen
10. Insulin-Like Growth Factor I (IGF-1)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Laminectomy
3. Transplants (Transplant)
4. Homologous Transplantation (Allograft)
5. Therapeutics