|1.||Chen, Jian: 2 articles (03/2012 - 01/2011)|
|2.||Duan, Zhi: 2 articles (03/2012 - 01/2011)|
|3.||Wang, Di: 2 articles (03/2012 - 01/2011)|
|4.||Chen, Hui: 2 articles (03/2012 - 01/2011)|
|5.||Aoki, Masahiro: 2 articles (11/2009 - 09/2008)|
|6.||Fujishita, Teruaki: 2 articles (11/2009 - 09/2008)|
|7.||Taketo, Makoto M: 2 articles (11/2009 - 09/2008)|
|8.||Reynolds, Paul R: 1 article (12/2015)|
|9.||Arroyo, Juan A: 1 article (12/2015)|
|10.||Wahlquist, Tyler: 1 article (12/2015)|
|1.||Breast Neoplasms (Breast Cancer)
07/01/2014 - "There are scarce data available on the prognostic/predictive value of p-Akt and p-mTOR protein expression in patients with high-risk early breast cancer. "
06/01/2010 - "Loss of PTEN protein expression appears to occur more frequently in women with a family history of breast cancer, whereas activation of mTOR protein seems to be related to a more aggressive phenotype."
07/01/2011 - "The mammalian target of rapamycin (mTOR)/PI3K/Akt pathway is altered in breast cancer cells, as demonstrated by mutations in both the upstream and downstream regulators of mTOR, including phosphatase and tensin homolog deleted in chromosome 10 (PTEN) loss or Akt/PI3K activation, and potentially in the mTOR protein itself. "
03/01/2014 - "In the BOLERO-2 study, the addition of everolimus, a selective inhibitor of mTOR protein, to exemestane was associated with a significant improvement in progression-free survival, compared to exemestane plus placebo, in patients with hormone receptor-positive, HER2-negative metastatic breast cancer, and resistant to non-steroidal aromatase inhibitor therapy. "
02/15/2012 - "Hyperactivation of the mTOR protein has been linked to development of cancer, raising mTOR as an attractive target for cancer therapy. "
12/09/2003 - "Frap (FKBP12 rapamycin-associated protein, mTOR, RAFT) was the only gene differing in amino acid sequence between alleles that correlated with strain sensitivity to tumor development. "
01/01/2011 - "Overexpression of total mTOR protein was significantly associated with T1/T2 stage tumors, lymph node metastasis, distal metastasis) and degree of differentiation. "
03/01/2009 - "Overexpression of total mTOR protein was significantly correlated with tumor differentiation, T1/T2 tumors, and stage I/II/III disease, whereas p-mTOR overexpression was significantly correlated with lymph node metastasis and all stage disease. "
01/15/2014 - "Active, phosphorylated mTOR displayed a 24-hour rhythm, and levels of total mTOR protein (but not mRNA) also showed a circadian rhythm in RenCa tumor masses. "
10/01/2013 - "In this study, we examined modulations in phosphatase and tensin homolog (PTEN) and mammalian target of rapamycin (mTOR) protein expression after a lateral C2 hemisection and subsequent intermittent hypoxia (IH) exposure and training, which initiates respiratory motor plasticity and recovery. "
06/01/2012 - "The mammalian target of rapamycin (MTOR) protein kinase complex is a key component of a pathway that regulates cell growth and proliferation in response to energy levels, hypoxia, nutrients and insulin. "
|4.||Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
|5.||Mitochondrial Diseases (Mitochondrial Disease)