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Class Ia Phosphatidylinositol 3-Kinase

A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS.
Also Known As:
Class Ia Phosphatidylinositol 3-Kinase, p110alpha Subunit; Class Ia Phosphatidylinositol 3-Kinase, p110beta Subunit; Class Ia Phosphatidylinositol 3-Kinase, p110delta Subunit; Class Ia Phosphatidylinositol 3-Kinase, p50alpha Subunit; Class Ia Phosphatidylinositol 3-Kinase, p55alpha Subunit; Class Ia Phosphatidylinositol 3-Kinase, p55gamma Subunit; Class Ia Phosphatidylinositol 3-Kinase, p85alpha Subunit; Class Ia Phosphatidylinositol 3-Kinase, p85beta Subunit; Class Ia Phosphatidylinositol 3-kinase, Regulatory, alpha Polypeptide; Class Ia Phosphatidylinositol 3-kinase, Regulatory, beta Polypeptide; Class Ia Phosphatidylinositol 3-kinase, Regulatory, gamma Polypeptide; Phosphatidylinositol 3-Kinase, Class Ia; Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide; Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide; Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide; Phosphoinositide-3-Kinase, Regulatory Subunit 1; Phosphoinositide-3-Kinase, Regulatory Subunit 2; Phosphoinositide-3-Kinase, Regulatory Subunit 3; alpha-P85 Subunit, PI-3K; p110alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase; p110beta Subunit, Class Ia Phosphatidylinositol 3-Kinase; p110delta Subunit, Class Ia Phosphatidylinositol 3-Kinase; p50alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase; p55alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase; p55gamma Subunit, Class Ia Phosphatidylinositol 3-Kinase; p85alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase; p85beta Subunit, Class Ia Phosphatidylinositol 3-Kinase; Class Ia Phosphatidylinositol 3 Kinase; Class Ia Phosphatidylinositol 3 Kinase, p110alpha Subunit; Class Ia Phosphatidylinositol 3 Kinase, p110beta Subunit; Class Ia Phosphatidylinositol 3 Kinase, p110delta Subunit; Class Ia Phosphatidylinositol 3 Kinase, p50alpha Subunit; Class Ia Phosphatidylinositol 3 Kinase, p55alpha Subunit; Class Ia Phosphatidylinositol 3 Kinase, p55gamma Subunit; Class Ia Phosphatidylinositol 3 Kinase, p85alpha Subunit; Class Ia Phosphatidylinositol 3 Kinase, p85beta Subunit; Class Ia Phosphatidylinositol 3 Kinases; PI-3K alpha-P85 Subunit; Phosphatidylinositol 3 Kinase, Class Ia; Phosphoinositide 3 Kinase, Regulatory Subunit 1; Phosphoinositide 3 Kinase, Regulatory Subunit 2; Phosphoinositide 3 Kinase, Regulatory Subunit 3; p110alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase; p110beta Subunit, Class Ia Phosphatidylinositol 3 Kinase; p110delta Subunit, Class Ia Phosphatidylinositol 3 Kinase; p50alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase; p55alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase; p55gamma Subunit, Class Ia Phosphatidylinositol 3 Kinase; p85alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase; p85beta Subunit, Class Ia Phosphatidylinositol 3 Kinase; Class Ia Phosphatidylinositol 3-Kinases
Networked: 26 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Newcomb, Polly A: 2 articles (07/2015 - 12/2013)
2. Phipps, Amanda I: 2 articles (07/2015 - 12/2013)
3. Ueki, Kohjiro: 2 articles (12/2012 - 12/2010)
4. Kadowaki, Takashi: 2 articles (12/2012 - 12/2010)
5. Cantley, Lewis C: 2 articles (12/2010 - 09/2010)
6. Cheng, Iona: 1 article (07/2015)
7. Burnett, Terrilea: 1 article (07/2015)
8. Ahnen, Dennis J: 1 article (07/2015)
9. Win, Aung Ko: 1 article (07/2015)
10. Ming, Huixin: 1 article (01/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Sarcoma (Soft Tissue Sarcoma)
06/01/2011 - "Expression of EGFR and phosphatase and tensin homolog (PTEN) were examined by immunohistochemistry, and mutation status of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) exon 2, V-raf murine sarcoma viral oncogene homolog B1 (BRAF) exon 15, phosphoinositide-3-kinase, catalytic, alpha polypeptide (PI3KCA) exons 9, 20, and PTEN exons 5-9 were analyzed by direct sequencing. "
12/01/2012 - "The p53 and phosphoinositide-3-kinase, catalytic, alpha polypeptide/v-akt murine thymoma viral oncogene homolog/mechanistic target of rapamycin (PIK3CA/AKT/mTOR) pathways frequently are altered in sarcoma with complex genomics, such as leiomyosarcoma (LMS) or undifferentiated pleomorphic sarcoma (UPS). "
12/01/2009 - "The activation of the downstream receptor pathways was also studied by means of v-akt murine thymoma viral oncogene homolog (AKT), extracellular signal-regulated kinase (ERK), and mammalian target of rapamycin (mTOR) Western blotting experiments, as well as rat sarcoma viral oncogene homolog (RAS), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), phosphoinositide-3-kinase, catalytic, alpha polypeptide (PI3KCA), and phosphatase and tensin homolog deleted on chromosome ten (PTEN) mutational analysis and fluorescence in situ hybridization. "
07/01/2014 - "Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate sarcoma viral oncogene homolog (KRAS), phosphoinositide-3-kinase catalytic alpha polypeptide (PIK3CA), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen activated protein kinase kinase 1 (MEK1), phosphatase and tensin homolog (PTEN), and human epidermal growth factor receptor 2 (HER2) in patient specimens and cell line DNA. "
3. Thymoma (Thymic Carcinoma)
4. Colorectal Neoplasms (Colorectal Cancer)
5. Lung Neoplasms (Lung Cancer)

Related Drugs and Biologics

1. tensins (tensin)
2. Sirolimus (Rapamycin)
3. Insulin (Novolin)
4. Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
5. Insulin Receptor Substrate Proteins
6. Proto-Oncogene Proteins c-akt (Protein Kinase B)
7. MAP Kinase Kinase 1
8. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9. MicroRNAs (MicroRNA)
10. Cyclin-Dependent Kinase Inhibitor p16