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Sotos Syndrome

Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.
Also Known As:
Cerebral Gigantism; Sotos Sequence; Sotos' Syndrome; Cerebral Gigantisms; Gigantism, Cerebral; Gigantisms, Cerebral; Sequence, Sotos; Soto Syndrome; Soto's Syndrome; Syndrome, Sotos; Syndrome, Sotos'
Networked: 105 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Intellectual Disability (Idiocy)
2. Kabuki syndrome
3. Sotos Syndrome
4. Megalencephaly
5. Inborn Genetic Diseases (Disease, Hereditary)

Experts

1. Matsumoto, Naomichi: 3 articles (01/2020 - 01/2004)
2. Tatton-Brown, Katrina: 3 articles (01/2019 - 10/2004)
3. Wit, J M: 3 articles (07/2006 - 04/2004)
4. Brennan, Kevin: 2 articles (01/2022 - 12/2017)
5. Fahrner, Jill A: 2 articles (01/2022 - 01/2019)
6. Gentles, Andrew J: 2 articles (01/2022 - 12/2017)
7. Gevaert, Olivier: 2 articles (01/2022 - 12/2017)
8. Shin, June Ho: 2 articles (01/2022 - 12/2017)
9. Sunwoo, John B: 2 articles (01/2022 - 12/2017)
10. Devriendt, Koenraad: 2 articles (12/2020 - 07/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sotos Syndrome:
1. Methylphenidate (Ritalin)FDA LinkGeneric
2. Histone MethyltransferasesIBA
3. Proteins (Proteins, Gene)FDA Link
4. Somatomedins (Somatomedin)IBA
5. NucleotidesIBA
6. CollagenIBA
7. Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
8. Histones (Histone)IBA
9. Growth Hormone (Somatotropin)IBA
10. DNA (Deoxyribonucleic Acid)IBA

Therapies and Procedures

1. Ligation
2. Anterior Temporal Lobectomy
3. Distraction Osteogenesis
4. Hip Replacement Arthroplasty (Total Hip Replacement)
5. Catheter Ablation